Metabolic and cardiovascular characteristics, and blood biochemistry
| All patients | Exercise status | |||
| Inactive | Active | P value | ||
| Metabolic and cardiovascular characteristics | ||||
| Cirrhosis (%) | 35 | 39 | 30 | 0.602* |
| Sustained virological response (%) | 72 | 71 | 71 | 0.998* |
| SBP (mm Hg) | 134±19 | 130±21 | 137±17 | 0.104† |
| DBP (mm Hg) | 83 (13) | 78 (11) | 86 (15) | 0.496‡ |
| Hypertensive (%) | 62 | 55 | 66 | 0.180* |
| Metabolic syndrome (%) | 27 | 30 | 25 | 0.620* |
| Metabolic syndrome features | 2 (2) | 2 (2) | 2 (2) | 0.359* |
| Dyslipidaemia (%) | 17 | 16 | 18 | 0.376* |
| Diabetes (%) | 15 | 16 | 14 | 1.000* |
| CVD (%) | 9 | 11 | 7 | 0.713* |
| CKD (%) | 2 | 5 | 0 | 0.494* |
| Depression (%) | 50 | 57 | 41 | 0.281* |
| Smoking (%) | 48 | 55 | 39 | 0.226* |
| QRISK3 | 11.69±11.32 | 11.57±12.62 | 11.82±9.97 | 0.922† |
| Biological age (years) | 60±13 | 59±14 | 62±12 | 0.255† |
| Blood biochemistry | ||||
| Platelets (109/L) | 229.68±94.48 | 225.07±87.08 | 234.40±102.35 | 0.652† |
| White cell count (109/L) | 7.55±2.41 | 7.63±2.81 | 7.48±1.94 | 0.771† |
| Albumin (g/L) | 45.92±3.23 | 44.93±3.01 | 46.95±3.15 | 0.004†§ |
| Bilirubin (μmol/L) | 7.50 (6.25) | 7.00 (7.00) | 8.00 (6.00) | 0.388‡ |
| ALP (μL/L) | 82.26±27.11 | 86.77±31.11 | 77.54±21.55 | 0.119† |
| ALT (U/L) | 28.00 (28.25) | 28.00 (33.00) | 28.00 (19.00) | 0.417‡ |
| GGT (U/L) | 40.00 (61.00) | 45.00 (100.00) | 33.00 (53.00) | 0.619‡ |
| AST (U/L) | 27.00 (19.75) | 26.50 (27.00) | 27.50 (17.35) | 0.588‡ |
| HbA1c (mmol/mol) | 38.00 (6.00) | 38.50 (6.00) | 38.00 (5.50) | 0.493‡ |
| Vitamin D (nmol/L) | 45.00 (42.50) | 37.00 (32.50) | 53.00 (36.50) | 0.580‡ |
| Total cholesterol (mmol/L) | 4.42±1.12 | 4.19±1.18 | 4.65±1.01 | 0.549† |
| Triglycerides (mmol/L) | 1.40 (0.95) | 1.69 (1.17) | 1.30 (1.00) | 0.611‡ |
| HDL (mmol/L) | 1.40 (0.50) | 1.40 (0.53) | 1.30 (0.55) | 0.837‡ |
| Cholesterol/HDL ratio (mmol/L) | 3.20 (1.49) | 2.95 (1.25) | 3.50 (1.41) | 0.604‡ |
| LDL (mmol/L) | 3.07±1.08 | 2.85±1.13 | 3.30±1.00 | 0.062† |
| TSH (mU/L) | 1.74 (1.16) | 1.75 (1.19) | 1.74 (0.41) | 0.410‡ |
**Between group difference at p<0.01; ***between group difference at p<0.001.
Metric and normally distributed variables are reported as mean±SD; non-normally distributed variables are reported as median and IQR, and categorical variables are reported as frequency (percentage).
*Fisher’s exact test.
†Independent t-test.
‡Mann-Whitney U test.
§Between group difference at p<0.05.
ALP, Alkaline Phosphatase; ALT, Alanine Aminotransferase; AST, Aspartate Aminotransferase; CKD, Chronic Kidney Disease; CVD, cardiovascular disease; DBP, Diastolic Blood Pressure; GGT, Gamma Glutamyl Transferase; HDL, High Density Lipoprotein; LDL, Low Density Lipoprotein; SBP, Systolic Blood Pressure; TSH, thyroid stimulating hormone.