Table 2

Accuracy estimates of 11 included studies

Test	Sensitivity (95% CI)	Specificity (95% CI)	AUROC (95% CI)	LR+ (95% CI)	LR− (95% CI)	Publication bias	I² (%)
Campylobacter
Luminex xTAG	0.92 (0.86 to 0.96)	0.98 (0.96 to 0.99)	0.99 (0.98 to 1.00)	55 (21 to 140)	0.08 (0.04 to 0.14)	0.94	95.73
FilmArray	0.95 (0.87 to 0.98)	0.99 (0.98 to 1.00)	0.99 (0.94 to 1.00)	120 (47 to 330)	0.05 (0.02 to 0.13)	0.93	63.26
Clostridium difficile
Luminex xTAG	0.95 (0.91 to 0.97)	0.98 (0.96 to 0.99)	0.99 (0.97 to 1.00)	49 (24 to 100)	0.06 (0.04 to 0.09)	0.07	88.33
FilmArray	0.97 (0.90 to 0.99)	0.97 (0.96 to 0.98)	1.00 (0.98 to 1.00)	35 (26 to 47)	0.03 (0.01 to 0.11)	0.54	10.43
E. coli O157
Luminex xTAG	0.87 (0.72 to 0.95)	0.99 (0.99 to 1.00)	0.96 (0.93 to 0.98)	150 (72 to 330)	0.13 (0.05 to 0.28)	0.72	71.10
ETEC
Luminex xTAG	0.88 (0.63 to 0.97)	0.99 (0.94 to 1.00)	0.99 (0.91 to 1.00)	60 (13 to 290)	0.13 (0.03 to 0.38)	0.42	64.46
FilmArray	0.92 (0.67 to 0.98)	0.99 (0.99 to 1.00)	1.00 (0.90 to 1.00)	150 (80 to 280)	0.08 (0.02 to 0.33)	0.19	0.00
Salmonella
Luminex xTAG	0.85 (0.80 to 0.90)	0.97 (0.92 to 0.99)	0.97 (0.95 to 0.98)	33 (11 to 100)	0.15 (0.11 to 0.21)	0.14	96.61
FilmArray	0.94 (0.84 to 0.98)	1.00 (0.99 to 1.00)	1.00 (0.98 to 1.00)	210 (110 to 400)	0.06 (0.02 to 0.16)	0.15	73.03
STEC stx1/stx2
Luminex xTAG	0.92 (0.81 to 0.97)	0.99 (0.99 to 1.00)	0.99 (0.96 to 1.00)	130 (65 to 270)	0.08 (0.03 to 0.19)	0.03	41.95
FilmArray	0.96 (0.85 to 0.99)	0.99 (0.99 to 1.00)	1.00 (0.96 to 1.00)	190 (100 to 350)	0.04 (0.01 to 0.15)	0.25	89.16
Shigella or Shigella/EIEC
Luminex xTAG	0.95 (0.88 to 0.98)	0.99 (0.97 to 0.99)	1.00 (0.99 to 1.00)	76 (36 to 160)	0.06 (0.02 to 0.12)	0.98	95.69
FilmArray	0.95 (0.87 to 0.98)	1.00 (0.99 to 1.00)	1.00 (0.99 to 1.00)	440 (170 to 1200)	0.05 (0.02 to 0.13)	0.15	35.89
Yersinia enterocolitica
Luminex xTAG	0.48 (0.31 to 0.65)	1.00 (0.99 to 1.00)	0.91 (0.81 to 1.00)	230 (45 to 1200)	0.53 (0.35 to 0.69)	0.93	72.88
Adenovirus 40/41
Luminex xTAG	0.70 (0.42 to 0.88)	0.99 (0.99 to 1.00)	0.96 (0.94 to 0.99)	96 (53 to 160)	0.30 (0.12 to 0.58)	0.78	2.23
FilmArray	0.90 (0.69 to 0.97)	0.99 (0.98 to 1.00)	0.99 (0.94 to 1.00)	100 (55 to 180)	0.10 (0.03 to 0.31)	0.04	86.80
Norovirus GI/GII
Luminex xTAG	0.88 (0.82 to 0.93)	0.98 (0.95 to 0.99)	0.97 (0.96 to 0.99)	37 (16 to 85)	0.12 (0.08 to 0.19)	0.85	89.74
FilmArray	0.92 (0.86 to 0.95)	0.99 (0.98 to 1.00)	0.99 (0.97 to 1.00)	120 (61 to 230)	0.08 (0.05 to 0.14)	0.85	71.76
Rotavirus A
Luminex xTAG	0.93 (0.90 to 0.96)	0.99 (0.98 to 1.00)	0.99 (0.99 to 1.00)	100 (52 to 200)	0.07 (0.04 to 0.10)	0.74	88.05
FilmArray	0.93 (0.75 to 0.98)	0.99 (0.97 to 0.99)	1.00 (0.96 to 1.00)	76 (35 to 160)	0.07 (0.02 to 0.25)	0.21	92.42
Cryptosporidium
Luminex xTAG	0.82 (0.63 to 0.92)	0.99 (0.97 to 1.00)	0.98 (0.89 to 1.00)	96 (22 to 410)	0.18 (0.08 to 0.37)	0.01	37.52
FilmArray	0.92 (0.68 to 0.98)	1.00 (0.99 to 1.00)	1.00 (0.92 to 1.00)	230 (110 to 490)	0.08 (0.02 to 0.32)	0.15	0.00
Entamoeba histolytica
Luminex xTAG	0.70 (0.33 to 0.92)	0.99 (0.97 to 0.99)	0.99 (0.85 to 1.00)	59 (18 to 160)	0.30 (0.08 to 0.68)	0.18	0.00
Giardia lamblia
Luminex xTAG	0.81 (0.52 to 0.94)	0.98 (0.95 to 0.99)	1.00 (0.95 to 1.00)	36 (13 to 85)	0.19 (0.06 to 0.49)	0.22	64.59
FilmArray	0.91 (0.69 to 0.98)	1.00 (0.99 to 1.00)	1.00 (0.93 to 1.00)	200 (100 to 390)	0.09 (0.02 to 0.31)	0.08	0.00
Astrovirus
FilmArray	0.96 (0.85 to 0.99)	1.00 (0.98 to 1.00)	0.99 (0.91 to 1.00)	300 (55 to 1600)	0.04 (0.01 to 0.15)	0.08	90.16
Sapovirus
FilmArray	0.96 (0.83 to 0.99)	0.99 (0.99 to 1.00)	1.00 (0.99 to 1.00)	170 (66 to 430)	0.04 (0.01 to 0.17)	0.35	84.54

AUROC, area under the receiver operating characteristic curve; E. coli, Escherichia coli; EIEC, Enteroinvasive Escherichia coli; ETEC, Enterotoxigenic Escherichia coli; LR−, negative likelihood ratio; LR+, positive likelihood ratio; STEC, Shiga-like Toxin producing Escherichia coli.