ICD-10-AM codes for aetiologies of chronic liver disease
| ICD-10-AM code | Encounters with code | PPV (95% CI) | NPV (95% CI) | Sensitivity (95% CI) | Specificity (95% CI) | Kappa | |
| Alcohol-related liver disease | |||||||
| F10.1 | Harmful use of alcohol | 111 | 0.95 (0.89 to 0.98) | 0.63 (0.57 to 0.70) | 0.59 (0.52 to 0.66) | 0.95 (0.91 to 0.98) | 0.51 |
| K70.1 | Alcoholic hepatitis | 9 | 1.00 | 0.44 (0.43 to 0.45) | 0.05 (0.03 to 0.09) | 1.00 | 0.04 |
| K70.2 | Alcoholic fibrosis and sclerosis of liver | 0 | – | – | – | – | – |
| K70.3 | Alcoholic cirrhosis of liver | 146 | 0.93 (0.88 to 0.96) | 0.74 (0.67 to 0.80) | 0.76 (0.69 to 0.82) | 0.92 (0.87 to 0.96) | 0.67 |
| K70.4 | Alcoholic hepatic failure | 65 | 0.95 (0.89 to 0.99) | 0.53 (0.46 to 0.59) | 0.35 (0.28 to 0.42) | 0.98 (0.94 to 0.99) | 0.30 |
| K70.9 | Alcoholic liver disease, unspecified | 0 | – | – | – | – | – |
| Grouped alcohol codes*† | 158 | 0.94 (0.89 to 0.97) | 0.81 (0.74 to 0.86) | 0.84 (0.78 to 0.89) | 0.92 (0.87 to 0.96) | 0.75 | |
| Hepatitis C‡ | |||||||
| B18.2 | Chronic viral hepatitis C | 85 | 0.95 (0.89 to 0.98) | 0.95 (0.92 to 0.97) | 0.88 (0.80 to 0.94) | 0.98 (0.96 to 0.99) | 0.88 |
| Z22.52 | Carrier of viral hepatitis C | 0 | – | – | |||
| Hepatitis B‡ | |||||||
| B18.0 | Chronic viral hepatitis B with delta-agent | 0 | – | – | |||
| B18.1 | Chronic viral hepatitis B without delta-agent | 18 | 0.56 (0.33 to 0.77) | 1.00 | 1.00 | 0.97 (0.95 to 0.99) | 0.70 |
| Z22.51 | Carrier of viral hepatitis B | 0 | – | – | |||
| NAFLD/NASH | |||||||
| K75.8 | Other specified inflammatory diseases of the liver | 48 | 0.92 (0.82 to 0.97) | 0.82 (0.77 to 0.86) | 0.48 (0.38 to 0.59) | 0.98 (0.96 to 0.99) | 0.54 |
| K76.0 | Fatty (change of) liver, not elsewhere classified | 10 | 0.90 (0.63 to 0.99) | 0.72 (0.67 to 0.77) | 0.10 (0.05 to 0.17) | 0.96 (0.98 to 1.00) | 0.13 |
| Grouped NAFLD/NASH codes† | 57 | 0.91 (0.82 to 0.97) | 0.84 (0.80 to 0.89) | 0.57 (0.47 to 0.67) | 0.98 (0.95 to 0.99) | 0.62 | |
*‘Grouped alcohol’ codes included: E24.4 ‘Alcohol induced pseudo-Cushing’s syndrome’, F10 code block ‘Mental and behavioural disorders due to use of alcohol’, G31.2 ‘Degeneration of nervous system due to alcohol’, G62.1 ‘Alcoholic polyneuropathy’, G72.1 ‘Alcoholic myopathy’, I42.6 ‘Alcoholic cardiomyopathy’, K29.2 ‘Alcoholic gastritis’, K29.20 ‘Alcoholic gastritis without mention of haemorrhage’, K29.21 ‘Alcoholic gastritis with haemorrhage’, K70 code block ‘Alcoholic liver disease’, K86.0 ‘Alcohol-induced chronic pancreatitis’, T51.0 ‘Toxic effect of alcohol, ethanol’, Z50.2 ‘Alcohol rehabilitation’, Z71.4 ‘Counselling and surveillance for alcohol use disorder’, Z72.1 ‘Alcohol use’.
†More than one code may have been assigned to the audited encounter.
‡Codes for acute viral hepatitis (including code blocks B16 ‘Acute hepatitis B’ and B17 ‘Other acute viral hepatitis’) were not included.
ICD-10-AM, International Classification of Diseases, Tenth Revision, Australian Modification; NAFLD, non-alcoholic fatty liver disease; NASH, non-alcoholic steatohepatitis; NPV, negative predictive value; PPV, positive predictive value.