Gene name | SNP ID | SNP in chromosome | Minor allele | Major allele | Frequency in clearance | Frequency in controls | p Value | OR | Function | |
---|---|---|---|---|---|---|---|---|---|---|
1 | TNR | rs2239818 | chr1_173642258 | A | G | 0.01 | 0.22 | 1.28E−05 | 0.04 | Receptor binding; negative regulation of cell adhesion |
2 | SPINT2 | rs3745948 | chr19_43471696 | T | C | 0.05 | 0.33 | 1.46E−05 | 0.12 | Serine-type endopeptidase inhibitor activity |
3 | TNR | rs34842046 | chr1_173559295 | T | A | 0.02 | 0.22 | 6.67E−05 | 0.08 | Receptor binding; negative regulation of cell adhesion |
4 | HTR3E | rs7627615 | chr3_185301110 | G | A | 0.35 | 0.04 | 8.81E−05 | 11.69 | Receptor activity; extracellular ligand-gated ion channel activity |
5 | TMPRSS11A | rs1370840 | chr4_68492841 | A | G | 0.31 | 0.02 | 0.000157 | 18.97 | TMPRSS11A expression in normal oesophagus, liver, colon and lung, with downregulated expression in tumours |
6 | TMPRSS11A | rs11930532 | chr4_68494878 | C | T | 0.29 | 0.02 | 0.000159 | 18.91 | TMPRSS11A expression in normal oesophagus, liver, colon and lung, with downregulated expression in tumours |
7 | TMPRSS11A | rs28437478 | chr4_68493016 | A | T | 0.29 | 0.02 | 0.000189 | 18.53 | TMPRSS11A expression in normal oesophagus, liver, colon and lung, with downregulated expression in tumours |
8 | SALL2 | rs1263810 | chr14_21061466 | G | C | 0.16 | 0.45 | 0.000206 | 0.23 | DNA binding; sequence-specific DNA binding transcription factor activity |
9 | SPATA 22 | rs9901726 | chr17_3290284 | T | C | 0.02 | 0.19 | 0.000223 | 0.09 | SPATA22 |
10 | SPATA 22 | rs2291604 | chr17_3299188 | G | C | 0.02 | 0.19 | 0.000223 | 0.09 | SPATA 22 |
11 | NMNAT2 | rs607332 | chr1_181519836 | A | G | 0.18 | 0.48 | 0.000227 | 0.24 | Nucleotide binding; nicotinamide-nucleotide adenylyltransferase activity |
12 | NCKAP1 | Novel | chr2_183540400 | T | C | 0.03 | 0.22 | 0.000266 | 0.11 | Protein binding; plasma membrane; apoptosis |
13 | SPATA 22 | rs9900543 | chr17_3296435 | C | T | 0.02 | 0.19 | 0.000316 | 0.09 | SPATA 22 |
14 | NCKAP1 | Novel | chr2_183501325 | T | C | 0.03 | 0.22 | 0.000319 | 0.12 | Protein binding; plasma membrane; apoptosis |
15 | MARVELD3 | rs2303225 | chr16_70232383 | C | G | 0.42 | 0.11 | 0.000333 | 5.61 | Membrane; integral to membrane; |
16 | TMPRSS11A | rs6552134 | chr4_68511802 | G | A | 0.27 | 0.02 | 0.00048 | 16.25 | TMPRSS11Aexpression in normal oesophagus, liver, colon and lung, with downregulated expression in tumours |
17 | ZNF491 | Novel | chr19_11778746 | A | C | 0.01 | 0.15 | 0.000525 | 0.06 | DNA binding; zinc ion binding |
18 | ZNF440 | Novel | chr19_11804552 | A | G | 0.01 | 0.15 | 0.000525 | 0.06 | DNA binding; zinc ion binding |
19 | ZNF439 | Novel | chr19_11840305 | G | C | 0.01 | 0.15 | 0.000525 | 0.06 | DNA binding; zinc ion binding |
20 | CA2 | rs2307075 | chr8_86575480 | C | A | 0.34 | 0.66 | 0.000528 | 0.27 | Kidney development; morphogenesis of an epithelium; carbonate dehydratase activity; protein binding |
CA2, carbonate dehydratase II; HTR3E, 5-hydroxytryptamine receptor 3 family member E; MARVELD3, MARVEL domain containing 3; NCKAP1, NCK-associated protein 1; NMNAT2, nicotinamide mononucleotide adenylyltransferase 2; SALL2, sal-like protein 2; SNP, single nucleotide polymorphism; SPATA 22, spermatogenesis associated 22; SPINT2, serine peptidase inhibitor, kunitz type 2; TMPRSS11A, transmembrane protease, serine 11A; TNR, tenascin receptor; ZNF, zinc finger protein;