Table 1

Baseline characteristics

Value	Training cohort				Validation cohort
Value	All patients n=127	Survivors n=92	Non-survivors n=35	P value	All patients n=80	Survivors n=62	Non-survivors n=18	P value
Age	74 (20–94) n=127	74 (20–94) n=92	73 (38–93) n=35	0.552	62 (23–90) n=80	59 (23–89) n=62	76 (36–90) n=18	0.002
Male	n=72/127 (56.7%)	n=49/92 (53.3%)	n=23/35 (65.7%)	0.234	n=45/80 (56.3%)	n=35/62 (56.5%)	n=10/18 (55.6%)	0.578
Living conditions	n=127			0.877
At home	n=82 (64.6%)	n=58 (63.0%)	n=24 (68.6%)
Nursing home	n=18 (14.2%)	n=14 (15.2%)	n=4 (11.4%)
Other clinic	n=27 (21.3%)	n=20 (21.7%)	n=7 (20.0%)
Hospitalisation <3 months	n=64/127 (50.4%)	n=49/92 (53.3%)	n=15/35 (42.9%)	0.326
Nosocomial infection	n=110/127 (86.6%)	n=77/92 (83.7%)	n=33/35 (94.3%)	0.151	n=60/80 (75.0%)	n=44/62 (71.0%)	n=16/18 (88.9%)	0.214
Charlson Comorbidity Index≥3	n=109/127 (85.5%)	n=76/92 (82.6%)	n=33/35 (94.3%)	0.152
Prior antibiotic treatment	n=78/127 (61.9%)	n=55/92 (60.4%)	n=23/35 (65.7%)	0.684
Diagnosis on normal ward	n=94/127 (74.0%)	n=71/92 (77.2%)	n=23/35 (65.7%)	0.257	n=58/80 (72.5%)	n=48/62 (77.4%)	n=10/18 (55.6%)	0.08
CRP in mg/L	114.25 (3.0–436.0) n=120	99.5 (3.0–289.0) n=85	151.0 (6.8–436.0) n=35	0.003	123.92 (1.9-452.4) n=58	115,3 (1.9–371.4) n=43	150.3 (14.7–452.4) n=15	0.265
WCC in x10ˆ9/L	12.4 (0.0–70.1) n=125	11.6 (0.0–41.4) n=90	15.0 (0.1–70.1) n=35	0.064
Temperature in °C	37.2 (36.0–39.8) n=125	37.4 (36.0–39.8) n=91	37.15 (36.0–38.7) n=34	0.248
Heartbeats/min	84 (50–130) n=125	82 (50–118) n=91	90 (60–130) n=34	0.044
Systolic blood pressure in mm Hg	109 (60–170) n=125	110 (60–170) n=91	99.5 (65–138) n=34	0.002	125.54 (60-166) n=80	117.5 (60–166) n=62	110 (65–145) n=18	0.100
Breaths/min	22 (11–32) n=37	21 (11–30) n=26	22 (12–32) n=11	0.402
SIRS criteria fulfilled	n=63/94 (67.0%)	n=41/66 (62.1%)	n=22/28 (78.6%)	0.153

Data are presented as mean (minimum–maximum) for continuous variables and absolute numbers (percentage) for discrete variables, respectively.
Crossed out parameters in the validation cohort were not systematically assessed.
CRP, C-reactive protein; SIRS, systemic inflammatory response syndrome ; WCC, white cell count.