Overview of the clinical and demographic features of the cohort
| Age (years) | 51.3±13.1 (range 24–80) |
| Gender | 67% male |
| White ethnicity | 93% |
| HCV treatment status | |
| HCV viraemia currently | 29% |
| Untreated | 24% |
| SVR | 71% |
| Failed antiviral treatment | 5% |
| Substance misuse | |
| Previous IDU | 60% |
| Current IDU | 7% |
| Current substance misuse | 24% |
| Stage of fibrosis | |
| Minimal or mild (LSM<8 kPa) | 54% |
| Moderate–advanced (8.0–12.5 kPa) | 12% |
| Cirrhosis (LSM>12.5 kPa) | 34% |
| BMI (kg/m2) | 27.9±6.0 |
| Normal (<25) | 34% |
| Overweight (25–29.9) | 28% |
| Obese (30+) | 38% |
| Waist circumference (cm) | |
| Men | 96.2±13.6 |
| Women | 94.4±16.9 |
| Central obesity on waist criteria | 37% |
| Met syndrome | 31% |
| Hypertension | 61% |
| Current treatment with antihypertensives | 27% |
| T2DM | 14% |
| Dyslipidaemia | 39% |
| Current treatment for dyslipidaemia | 10% |
| Number of Met syndrome features | |
| 0 | 20% |
| 1 | 28% |
| 2 | 21% |
| 3 | 21% |
| 4 | 8% |
| 5 | 2% |
| Fat mass (%) | |
| Males (n=41) | 28.7 (range 6.7–45.4, IQR 21.8–33.1) |
| Females (n=17) | 39.0 (range 12.4–54.5, IQR 26.9–41.6) |
| Smoking | |
| Never | 21% |
| Previous | 25% |
| Current | 54% |
| QRISK3 | |
| Risk of CV event in 10 years (%) | 8.2 (range 0.3–63; IQR 3.1–16.2) |
| ‘Heart age’ | 62 (range 32–83; IQR 51–71) |
| Difference between heart age and actual age | +7(range −4 to +26, IQR +4–+12) |
| >10% risk of CV event in 10 years | 45% |
| Alcohol | |
| Current consumption (units week) | 0 (range 0–280, IQR 0–10) |
| Current consumption >14 units/week | 23% |
| Previous ‘heavy’ alcohol consumption | 44% |
| AUDIT score | 3 (range 0–34, IQR 0–10) |
| <8 | 71% |
| 8–14 | 16% |
| 15–19 | 6% |
| 20+ | 7% |
| History of mental health disorder | 53% |
| Current regular physical activity level | |
| Sedentary | 59% |
| Moderate activity | 26% |
| Vigorous activity | 15% |
| Index of Multiple Deprivation (decile) | |
| 1 | 31 |
| 2 | 10 |
| 3 | 18 |
| 4 | 12 |
| 5 | 5 |
| 6 | 5 |
| 7 | 4 |
| 8 | 6 |
| 9 | 6 |
| 10 | 3 |
AUDIT, Alcohol Use Disorders Identification Test; BMI, body mass index; CV, cardiovascular; HCV, hepatitis C virus; IDU, injecting drug used; LSM, liver stiffness measurement; Met, metabolic; SVR, sustained virological response; T2DM, type 2 diabetes mellitus.