COVID-19 associated biochemical markers, LS and clinical course
| No liver damage (LS <5 kPa) n=20 | Liver damage (LS >5 kPa) n=12 | P value | |
| Spleen size (cm) | 10.8 (±2.1) | 11.1 (±1.9) | 0.44 |
| Liver stiffness (kPA) | 3.4 (±1.2) | 7.8 (±1.8) | 0.001* |
| IQR/M liver | 0.5 (±0.3) | 1.5 (±0.4) | n.a. |
| CAP (dB/m) | 213.1 (±61.5) | 212.2 (±80.4) | 0.70 |
| Spleen stiffness (kPA) | 28.1 (±19.8) | 30.4 (±10.7) | 0.78 |
| IQR/M spleen | 0.6 (±0.2) | 8.6 (±3.7) | n.a. |
| Bilirubin (mg/dL) | 0.43 (±0.22) | 0.42 (±0.2) | 0.43 |
| AST (U/L) | 19.5 (±5.3) | 67.1 (±31.5) | 0.001* |
| ALT (U/L) | 31.3 (±8.3) | 76.3 (30.6) | 0.001* |
| GGT (U/L) | 31.3 (±14.3) | 92.3 (±51.4) | 0.001* |
| Alkaline phosphatase (U/L) | 255.6 (±59.6) | 306.4 (±112.5) | 0.12 |
| Creatine kinase (U/L) | 118.6 (±58.7) | 96.5 (±42.9) | 0.73 |
| Troponin T (ng/L) | 18.2 (±13.2) | 12.1 (±4.2) | 0.62 |
| Creatinine (mg/dL) | 0.9 (±0.3) | 0.9 (±0.3) | ˃0.99 |
| BMI (kg/m2) | 24.1 (±3.2) | 24.7 (±2.7) | 0.58 |
| Max. AST (U/L) | 49.6 (±21.3) | 83.7 (±27.2) | 0.001* |
| Max. ALT (U/L) | 46.6 (±13.6) | 72.5 (±26.2) | 0.001* |
| SBP (mm Hg)* | 115.7 (±7.6) | 115.1 (±11.1) | 0.99 |
| MBP (mm Hg)* | 91.6 (±7.4) | 92 (±9.2) | 0.58 |
| DBP (mm Hg)* | 67.5 (±9.5) | 68.3 (±13.4) | 0.67 |
| LDH (U/L) | 72.5 (±33.5) | 79.9 (±28.8) | 0.54 |
| CRP (mg/dL) | 5.7 (±4.5) | 5.1 (±3.0) | 0.70 |
| Leucocytes (g/L) | 5.0 (±2.1) | 5.9 (±3.9) | 0.41 |
| Haemoglobin (g/L) | 127.3 (±15.3) | 125.1 (±15.9) | 0.70 |
| Platelet count (103/µL) | 226.1 (±89.4) | 233.7 (±87.5) | 0.82 |
| Quick % | 96.1 (±10.2) | 101,8 (±14.8) | 0.23 |
| Ferritin (µg/L) | 409.1 (±357.8) | 1019.8 (±761.2) | 0.05* |
| Onset of symptoms before admission to hospital (days) | 2.4 (±1.3) | 2.8 (±1.7) | 0.61 |
| Length of stay (days) | 8 (±1.4) | 15 (±7) | 0.001* |
| Admission to ICU | 0% | 25% | 0.007* |
| Mortality | 0% | 17% | 0.001* |
bold indicates statistical significant.
*SBP, MBP and DBP are given as mean±SD during hospital stay.
ALT, alanine transferase; AST, alanine transferase; BMI, body mass index; CAP, controlled attenuation parameter; CRP, C reactive protein; DBP, diastolic blood pressure; GGT, gamma glutamyl transferase; IQR/M, IQR/median value; LS, liver stiffness; MBP, mean blood pressure; SBP, systolic blood pressure.