Table 1

Effect of 5 days of recombinant Dickkopf (100 ng subcutaneously) treatment on the small intestine of 16-day-old rats

GroupCrypt fissionMitotic count/crypt sectionLGR5 count/crypt section
Control11 (2.0)*2.0 (0.4)†2.8 (0.4)*
Dickkopf-treated3 (0.6)*2.0 (0.4)†1.2 (0.2)*

  • Data are given as mean (SD) of five animals in each group.

  • *P<0.0001.

  • †Not significant.

  • LGR5, leucine-rich repeat-containing G-protein coupled receptors.