Table 2

Gastrointestinal Symptom Rating Scale. Moderate or severe symptoms (15 items)

	NDBO n=305	DBO n=48	GORD n=131	Colonic polyp n=150	Healthy n=47
(1) Abdominal pains	13.2% (39)	9.1% (4)	19.5% (24)	10.1% (14)	0.0% (0)
(1) Abdominal pains		p=0.208	p=0.126	p=0.073	p=<0.001*
(2) Heartburn	11.2% (33)	2.2% (1)	31.3% (40)	6.3% (9)	2.1% (1)
(2) Heartburn		p=0.172	p=<0.001*	p=0.011*	p=0.063
(3) Acid regurgitation	10.0% (30)	4.3% (2)	25.2% (32)	2.8% (4)	0.0% (0)
(3) Acid regurgitation		p=0.31	p=0.001*	p=<0.001*	p=<0.001*
(4) Hunger pains	9.5% (28)	6.7% (3)	15.1% (19)	2.8% (4)	0.0% (0)
(4) Hunger pains		p=0.349	p=0.311	p=0.013*	p=0.019*
(5) Nausea	3.7% (11)	2.2% (1)	7.1% (9)	0.0% (0)	0.0% (0)
(5) Nausea		p=0.125	p=<0.001*	p=0.009*	p=0.008*
(6) Rumbling	10.4% (31)	4.7% (2)	11.7% (15)	8.3% (12)	2.1% (1)
(6) Rumbling		p=0.031*	p=0.148	p=0.187	p=0.056
(7) Abdominal bloating	16.6% (49)	6.7% (3)	18.0% (23)	9.0% (13)	0.0% (0)
(7) Abdominal bloating		p=0.053	p=0.553	p=0.097	p=<0.001*
(8) Belching	11.1% (33)	6.5% (3)	25.6% (33)	2.1% (3)	0.0% (0)
(8) Belching		p=0.63	p=<0.001*	p=<0.001*	p=<0.001*
(9) Increased flatus	14.0% (42)	15.2% (7)	27.5% (36)	8.9% (13)	0.0% (0)
(9) Increased flatus		p=0.581	p=0.002*	p=0.417	p=<0.001*
(10) Decreased stools	25.5% (73)	19.1% (9)	31.5% (40)	21.6% (30)	15.2% (7)
(10) Decreased stools		p=0.433	p=0.014*	p=0.771	p=0.207
(11) Increased stools	5.9% (17)	8.5% (4)	5.5% (7)	4.3% (6)	4.3% (2)
(11) Increased stools		p=0.193	p=0.323	p=0.85	p=0.261
(12) Loose stools	6.8% (20)	4.4% (2)	9.8% (12)	6.3% (9)	2.1% (1)
(12) Loose stools		p=0.357	p=0.044*	p=0.391	p=<0.001*
(13) Hard stools	9.5% (28)	8.9% (4)	17.1% (21)	9.1% (13)	0.0% (0)
(13) Hard stools		p=0.715	p=0.004*	p=0.737	p=0.009*
(14) Urgency	8.5% (25)	11.1% (5)	8.9% (11)	7.0% (10)	0.0% (0)
(14) Urgency		p=0.572	p=0.207	p=0.752	p=<0.001*
(15) Incomplete evacuation	10.9% (32)	4.4% (2)	16.3% (20)	7.7% (11)	2.1% (1)
(15) Incomplete evacuation		p=0.157	p=0.049*	p=0.539	p=0.007*

This table compares all groups to the non-dysplastic BO cohort for each item of the GSRS. p values are derived by Fisher’s exact test.
*p values <0.05 were deemed statistically significant.
BO, Barrett’s oesophagus; DBO, dysplastic Barrett’s oesophagus; GORD, gastro-oesophageal reflux disease; GSRS, Gastrointestinal Symptom Rating Scale; NDBO, non-dysplastic Barrett’s oesophagus.