Table 1

Clinically significant disease frequency based on predominant symptom/indications

Symptoms (total)FindingsNo (%)Diagnostic yieldOR (95% CI, p value)
Diarrhoea
(total=188)
CRC5 (3)5.3% (n=59/1116)3.15 (2.22 to 4.47, p<0.0001)
HRA7 (4)
Angiodysplasia2 (1)
Inflammation—IBD31 (16)
Inflammation—Microscopic Colitis7 (4)
Inflammation—non-specific7 (4)
Negative129 (69)
PR bleeding
(total=148)
CRC9 (6)2.9% (n=32/1116)1.9 (1.24 to 2.9, p=0.003)
HRA12 (8)
Inflammation—IBD6 (4)
Inflammation—microscopic colitis1 (1)
Inflammation—non-specific3 (2)
Angiodysplasia1 (1)
Negative116(79)
Anaemia
(total=212)
CRC4 (2)2.2%
(n=25/1116)
0.83 (0.53 to 1.29, p=0.4)
HRA12 (6)
Inflammation—IBD5 (2)
Inflammation—non-specific2 (1)
Angiodysplasia2 (1)
Negative187 (88)
Weight loss
(total=37)
HRA3 (8)0.4%
(n=4/1116)
0.79 (0.28 to 2.24, p= 0.65)
Inflammation—IBD1 (3)
Negative35 (94)
Constipation
(total=57)
HRA2 (4)0.4%
(n=5/1116)
0.57 (0.22 to 1.45, p=0.12)
Inflammation—IBD1 (2)
Angiodysplasia1 (2)
Negative53 (93)
Alternating constipation and diarrhoea
(total=79)
CRC1 (1)1% (n= 12/1116)1.23 (0.65 to 2.33, p=0.52)
HRA2 (3)
Inflammation—IBD6 (8)
Inflammation—microscopic colitis1 (1)
Inflammation—non-specific2 (3)
Negative67 (85)
Abdominal pain
(total=104)
CRC1 (1)0.8%
(n=9/1116)
0.7 (0.37 to 1.33, p=0.28)
HRA1 (1)
Inflammation—IBD4 (4)
Inflammation—non-specific3 (3)
Negative95 (91)
  • CRC, colorectal cancer; HRA, high-risk adenoma; IBD, inflammatory bowel disease; PR, per rectum.