Table 3

Proportion of patients with normal and abnormal liver enzyme levels at each study visit

Laboratory valueBaselinea12 weeksb24 weeksc
Alanine aminotransferase (U/L)n=2843n=2697n=2764
 Normal (M<41, F<33)1028 (36.2)1427 (52.9)2095 (75.8)
 Abnormal (1–2 times upper limit)1286 (45.2)1127 (41.8)622 (22.5)
 >2 times upper limit529 (18.6)143 (5.3)47 (1.7)
Aspartate aminotransferase (U/L)n=2843n=2696n=2761
 Normal (M<50, F<35)1487 (52.3)1907 (70.7)2464 (89.2)
 Abnormal (1–2 times upper limit)1162 (40.9)754 (28.0)278 (10.1)
 >2 times upper limit194 (6.8)35 (1.3)19 (0.7)
Gamma-glutamyl transferase (U/L)n=2076n=1936n=1964
 Normal (M<49, F<32)827 (39.8)1017 (52.5)1228 (62.5)
 Abnormal (1–2 times upper limit)928 (44.7)759 (39.2)666 (33.9)
 >2 times upper limit321 (15.5)160 (8.3)70 (3.6)
  • Data are expressed as n (%). Percentages are calculated as n/N.

  • P value (χ2 test with Benjamini-Hochberg correction for multiple comparisons): b vs a, p<0.001, c vs a, p<0.001, c vs b, p<0.001.

  • F, female; M, male.