Demographic characteristics of CRC cases versus normal colonoscopy controls
| Demographics | Total CRC n=21 744 | Proximal n=7688 | Distal n=7039 | Rectal n=7017 | Controls* n=612 646 |
| Age, median (Q1–Q3) | 68 (60–76) | 71 (62–78) | 66 (60–75) | 65 (59–74) | 61 (55–68) |
| Sex, n (%) | |||||
| Male | 21 364 (98.3) | 7514 (97.7) | 6923 (98.4) | 6927 (98.7) | 580 369 (94.7) |
| Female | 380 (1.7) | 174 (2.3) | 116 (1.6) | 90 (1.3) | 32 277 (5.3) |
| Race/ethnicity, n (%) | |||||
| Non-Hispanic white | 14 838 (68.2) | 5076 (66.0) | 4752 (67.5) | 5010 (71.4) | 420 131 (68.6) |
| Non-Hispanic black | 3735 (17.2) | 1559 (20.3) | 1216 (17.3) | 960 (13.7) | 104 292 (17.0) |
| Hispanic | 959 (4.4) | 303 (3.9) | 347 (4.9) | 309 (4.4) | 23 994 (3.9) |
| Asian/Pacific Islander | 177 (0.8) | 53 (0.7) | 60 (0.9) | 64 (0.9) | 7306 (1.2) |
| American Indian/Alaska Native | 95 (0.4) | 32 (0.4) | 25 (0.4) | 38 (0.5) | 3177 (0.5) |
| Other/multiracial | 383 (1.8) | 124 (1.6) | 142 (2.0) | 117 (1.7) | 11 991 (2.0) |
| Unknown | 1557 (7.2) | 541 (7.0) | 497 (7.1) | 519 (7.4) | 41 755 (6.8) |
| BMI, median (Q1–Q3) | 27.9 (24.7–31.7) | 27.9 (24.7–31.7) | 28.4 (25.2–32.3) | 27.3 (24.1–31.0) | 28.9 (25.8–32.5) |
| BMI (categorical), n (%) | |||||
| Underweight | 299 (1.4) | 100 (1.3) | 74 (1.1) | 125 (1.8) | 3624 (0.6) |
| Normal | 4788 (22.0) | 1667 (21.7) | 1350 (19.2) | 1771 (25.2) | 101 309 (16.5) |
| Overweight | 7187 (33.1) | 2558 (33.3) | 2340 (33.2) | 2289 (32.6) | 215 161 (35.1) |
| Obese | 6437 (29.6) | 2266 (29.5) | 2337 (33.2) | 1834 (26.1) | 221 178 (36.1) |
| Unknown | 3033 (13.9) | 1097 (14.3) | 938 (13.3) | 998 (14.2) | 71 374 (11.7) |
| Height, median (Q1–Q3) | 69.8 (68–71.5) | 69.5 (67.8–71.5) | 70 (68–71.8) | 69.8 (68–71.5) | 69.6 (67.5–71.5) |
| Diabetes, n (%) | 6085 (28.0) | 2371 (30.8) | 2004 (28.5) | 1710 (24.4) | 148 293 (24.2) |
| Smoking status, n (%) | |||||
| Current | 4486 (20.6) | 1482 (19.3) | 1362 (19.3) | 1642 (23.4) | 128 211 (20.9) |
| Former | 3928 (18.1) | 1451 (18.9) | 1301 (18.5) | 1176 (16.8) | 117 281 (19.1) |
| Never | 5390 (24.8) | 2100 (27.3) | 1750 (24.9) | 1540 (21.9) | 181 118 (29.6) |
| Unknown | 7940 (36.5) | 2655 (34.5) | 2626 (37.3) | 2659 (37.9) | 186 036 (30.4) |
| Aspirin exposure, n (%) | 7639 (35.1) | 3008 (39.1) | 2511 (35.7) | 2120 (30.2) | 210 518 (34.4) |
*The demographic variables were compared among groups using Kruskal-Wallis test and χ2 test, all p values were <0.001.
BMI, body mass index; CRC, colorectal cancer; Q1, first quartile; Q3, third quartile.