Table 4

Correlates of the number of high dose (>90 daily OME) opioid prescriptions

	Cirrhosis				Hepatitis C without cirrhosis
	Mean # high dose prescriptions	RR	95% CI	P value	Mean # high dose prescriptions	RR	95% CI	P value
Age (years)
≤18	4.4	0.46	0.37 to 0.57	<0.001	4.6	0.35	0.29 to 0.41	<0.001
19–39	6.8	1.20	1.12 to 1.28	<0.001	6.6	1.07	1.00 to 1.14	0.051
40–59	8.5	1.32	1.27 to 1.37	<0.001	10.0	1.17	1.11 to 1.23	<0.001
≥60	5.1	1.00	Reference		6.6	1.00	Reference
Sex
Male	7.6	1.26	1.21 to 1.30	<0.001	9.3	1.30	1.26 to 1.35	<0.001
Female	7.2	1.00	Reference		8.5	1.00	Reference
Geographic region
Northeast	8.2	0.93	0.87 to 0.98	0.008	10.0	0.84	0.79 to 0.89	<0.001
North Central	6.8	0.71	0.67 to 0.75	<0.001	8.3	0.69	0.65 to 0.73	<0.001
South	6.8	0.65	0.62 to 0.69	<0.001	8.1	0.70	0.67 to 0.74	<0.001
West	8.7	1.00	Reference		10.1	1.00	Reference
Substance abuse/mental health diagnosis
Yes	9.6	1.29	1.24 to 1.35	<0.001	10.8	1.62	1.55 to 1.69	<0.001
No	6.6	1.00	Reference		8.1	1.00	Reference
Charlson comorbidity index
2 or higher	7.3	1.25	1.20 to 1.29	<0.001	9.8	1.13	1.08 to 1.19	<0.001
0–1	7.5	1.00	Reference		8.8	1.00	Reference
Aetiology of liver disease					N/A
Alcoholic cirrhosis with HCV	9.7	1.25	1.17 to 1.33	<0.001
Alcoholic cirrhosis (without HCV)	7.2	0.98	0.93 to 1.03	0.353
HCV cirrhosis (without alcohol)	9.4	1.19	1.13 to 1.25	<0.001
Other cirrhosis*	6.3	1.00	Reference

*Includes all forms of cirrhosis excluding HCV and alcoholic related cirrhosis.
HCV, hepatitis C virus;N/A, not applicable; OME, opioid morphine equivalents; RR, relative risk.