Database (Study) | Sample type | Sequencing method | Primers* | Species/OTUs† | Sample source (N) | Sample size by group | Average BMI | P (obese vs non-obese)‡ | ||
Obese | Non-obese | Obese | Non-obese | |||||||
Baxter et al 11 (2016) | Stool | 16S rRNA | V4 | 9997 | Carcinoma (318); control (172) | 118 | 368 | 34.05 | 24.93 | <0.001 |
Feng et al 10 (2015) | Stool | WGS | NA | 408 772 | Adenoma (42); carcinoma (41); control (55) | 43 | 113 | 31.98 | 25.62 | <0.001 |
Vogtmann et al (2016) | Stool | WGS | NA | 356 748 | Carcinoma (52); control (52) | 13 | 69 | 32.57 | 23.58 | <0.001 |
Zackular et al 6 (2014) | Stool | 16S rRNA | V4 | 24 990 | Adenoma (30); carcinoma (30); control (30) | 26 | 56 | 33.84 | 25.09 | 0.002 |
Zeller et al (2014a) | Stool | 16S rRNA | V4 | 9969 | Control (75); CRC (41) | 19 | 108 | 32.53 | 24.13 | <0.001 |
Zeller et al (2014b) | Tissue | 16S rRNA | V4/V3-4 | 9988 | Carcinoma (48); carcinoma-adjacent (48) | 14 | 80 | 33.3 | 24.5 | <0.001 |
Zeller et al (2014c) | Stool | WGS | NA | 327 491 | Adenoma (42); carcinoma (53); control (297) | 34 | 160 | 32.15 | 24.18 | <0.001 |
*1 Primers are NA for WGS.
†Average number of observed taxanomonic units (16S rRNA) or species (WGS). Averages were rounded to nearest whole number.
‡Test of the equality of proportion of individuals that are obese vs non-obese.
BMI, body mass index; WGS, whole genome sequencing.