Table 1

Summary of demographic characteristics, sequencing methods and OTUs for included data sources

Database (Study)Sample typeSequencing methodPrimers*Species/OTUs†Sample source (N)Sample size by groupAverage BMIP
vs non-obese)‡
Baxter et al 11 (2016)Stool16S rRNAV49997Carcinoma (318); control (172)11836834.0524.93<0.001
Feng et al 10 (2015)StoolWGSNA408 772Adenoma (42); carcinoma (41); control (55)4311331.9825.62<0.001
Vogtmann et al (2016)StoolWGSNA356 748Carcinoma (52); control (52)136932.5723.58<0.001
Zackular et al 6 (2014)Stool16S rRNAV424 990Adenoma (30); carcinoma (30); control (30)265633.8425.090.002
Zeller et al (2014a)Stool16S rRNAV49969Control (75); CRC (41)1910832.5324.13<0.001
Zeller et al (2014b)Tissue16S rRNAV4/V3-49988Carcinoma (48); carcinoma-adjacent (48)148033.324.5<0.001
Zeller et al (2014c)StoolWGSNA327 491Adenoma (42); carcinoma (53); control (297)3416032.1524.18<0.001
  • *1 Primers are NA for WGS.

  • †Average number of observed taxanomonic units (16S rRNA) or species (WGS). Averages were rounded to nearest whole number.

  • ‡Test of the equality of proportion of individuals that are obese vs non-obese.

  • BMI, body mass index; WGS, whole genome sequencing.