Table 3

Proportion of patients who progressed to MSAP or SAP among those who had presented with AP symptoms at hospital admission

Author, year; country	Study design and setting	Study population	Sample size (patients with AP symptoms)	MSAP cases		SAP cases
Author, year; country	Study design and setting	Study population	Sample size (patients with AP symptoms)	Number	Proportion	Number	Proportion (%)
USA studies
Single-centre hospital
Bhat et al, 200718; USA	Prospective cohort; hospital	Consecutive patients with AP admitted to a single hospital within 48 hours of onset of symptoms between June 2003 and January 2005	91	NR	NR	19*^a	20.9
Koutroumpakis et al, 201719; Koutroumpakis et al, 201420; USA	Prospective cohort; hospital	Patients with AP enrolled at single centre from 2003 to 2014	400	94	23.5%	98	24.5
Kwong et al, 201621; USA	Retrospective cohort; secondary care	Consecutive patients admitted with AP to single institution from November 2010 to December 2013	514	65	13%	15*^b	3
Talukdar et al, 201224; USA	Prospective cohort study; three hospitals	Consecutive patients with AP presented at a single institution between June 2004 and August 2005	137	27	19.7%	15*^c	10.9
EU-5 studies
Single-centre hospital
Gonzelez et al, 201125; UK	Retrospective study of prospective data; tertiary referral centre	Patients admitted with AP to tertiary referral centre between January 2008 and December 2009	127	NR	NR	32*^c	25.2
Multicentre hospital
De Rai et al, 201034; Italy	Prospective cohort; 56 centres	National sample of patients with AP admitted to hospital between July 2002 and December 2011	1173	NR	NR	167*^c	14.2
Mole et al, 201633; UK†	Retrospective cohort; 16 health boards	National sample of patients admitted to hospital for AP between April 2009 and March 2012	2053	NR	NR	390*^d	19
ICU setting
Harrison et al, 200727; UK	Retrospective cohort; general critical care units	ICNARC coding	219 468	NR	NR	2677	1.2

Only studies with unselected populations for specific characteristics or comorbidities are presented.
*Severity assessment criteria: (a) APACHE II and Ranson score, (b) RAC, 2012, (c) Atlanta classification, 1992, (d) clinical presentation.
†Study providing information on the size of the subgroup with SAP populations among all those who presented with AP, included for the reporting of epidemiological outcomes.
AP, acute pancreatitis; APACHE, Acute Physiology And Chronic Health Evaluation; EU-5, European Union-5; ICNARC, Intensive Care National Audit and Research Centre; ICU, intensive care unit; MSAP, moderately severe acute pancreatitis; NR, not reported; RAC, revised Atlantic classification; SAP, severe acute pancreatitis; UK, United Kingdom; USA, United States of America.