RT Journal Article
SR Electronic
T1 Variables associated with progression of moderate-to-severe Crohn’s disease
JF BMJ Open Gastroenterology
JO BMJ Open Gastro
FD BMJ Publishing Group Ltd
SP e001016
DO 10.1136/bmjgast-2022-001016
VO 9
IS 1
A1 Carolina da Silva Beda Sacramento
A1 Marina Pamponet Motta
A1 Candida de Oliveira Alves
A1 Jaciane Araujo Mota
A1 Lina Maria Goes de Codes
A1 Reginaldo Freitas Ferreira
A1 Pedro de Almeida Silva
A1 Larissa do Prado Palmiro
A1 Rafael Miranda Barbosa
A1 Mariana Nery Andrade
A1 Vitor Damasceno Andrade
A1 Vitor Brandão Vasconcelos
A1 Bernardo Wasconcellos Thiara
A1 Eduardo Martins Netto
A1 Genoile Oliveira Santana
YR 2022
UL http://bmjopengastro.bmj.com//content/9/1/e001016.abstract
AB Objective Determine the variables associated with hospitalisations in patients with Crohn’s disease and those associated with surgery, intestinal resection, hospital readmission, need for multiple operations and immunobiological agent use.Design A cross-sectional study was conducted from 2019 to 2021, using two centres for inflammatory bowel diseases in the Brazilian Public Health System.Results This study included 220 patients. Only perianal disease was associated with hospitalisation (31.6% vs 13.0%, p=0.012). Stricturing or penetrating behaviour (35.8% vs 12.6%, p<0.001) and perianal disease (45.9% vs 9.9%, p<0.001) were associated with surgery. Ileal or ileocolonic location (80.0% vs 46.5%, p=0.044) and stricturing or penetrating behaviour (68.0% vs 11.2%, p<0.001) were associated with intestinal resection. Steroids use at first Crohn’s disease occurrence and postoperative complications were associated with hospital readmission and need for multiple operations, respectively. Age below 40 years at diagnosis (81.3% vs 62.0%, p=0.004), upper gastrointestinal tract involvement (21.8% vs 10.3%, p=0.040) and perianal disease (35.9% vs 16.3%, p<0.001) were associated with immunobiological agent use.Conclusion Perianal disease and stricturing or penetrating behaviour were associated with more than one significant outcome. Other variables related to Crohn’s disease progression were age below 40 years at diagnosis, an ileal or ileocolonic disease localisation, an upper gastrointestinal tract involvement, the use of steroids at the first Crohn’s disease occurrence and history of postoperative complications. These findings are similar to those in the countries with a high prevalence of Crohn’s disease.Data are available on reasonable request. The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.