TY - JOUR T1 - Variables associated with progression of moderate-to-severe Crohn’s disease JF - BMJ Open Gastroenterology JO - BMJ Open Gastro DO - 10.1136/bmjgast-2022-001016 VL - 9 IS - 1 SP - e001016 AU - Carolina da Silva Beda Sacramento AU - Marina Pamponet Motta AU - Candida de Oliveira Alves AU - Jaciane Araujo Mota AU - Lina Maria Goes de Codes AU - Reginaldo Freitas Ferreira AU - Pedro de Almeida Silva AU - Larissa do Prado Palmiro AU - Rafael Miranda Barbosa AU - Mariana Nery Andrade AU - Vitor Damasceno Andrade AU - Vitor Brandão Vasconcelos AU - Bernardo Wasconcellos Thiara AU - Eduardo Martins Netto AU - Genoile Oliveira Santana Y1 - 2022/11/01 UR - http://bmjopengastro.bmj.com//content/9/1/e001016.abstract N2 - Objective Determine the variables associated with hospitalisations in patients with Crohn’s disease and those associated with surgery, intestinal resection, hospital readmission, need for multiple operations and immunobiological agent use.Design A cross-sectional study was conducted from 2019 to 2021, using two centres for inflammatory bowel diseases in the Brazilian Public Health System.Results This study included 220 patients. Only perianal disease was associated with hospitalisation (31.6% vs 13.0%, p=0.012). Stricturing or penetrating behaviour (35.8% vs 12.6%, p<0.001) and perianal disease (45.9% vs 9.9%, p<0.001) were associated with surgery. Ileal or ileocolonic location (80.0% vs 46.5%, p=0.044) and stricturing or penetrating behaviour (68.0% vs 11.2%, p<0.001) were associated with intestinal resection. Steroids use at first Crohn’s disease occurrence and postoperative complications were associated with hospital readmission and need for multiple operations, respectively. Age below 40 years at diagnosis (81.3% vs 62.0%, p=0.004), upper gastrointestinal tract involvement (21.8% vs 10.3%, p=0.040) and perianal disease (35.9% vs 16.3%, p<0.001) were associated with immunobiological agent use.Conclusion Perianal disease and stricturing or penetrating behaviour were associated with more than one significant outcome. Other variables related to Crohn’s disease progression were age below 40 years at diagnosis, an ileal or ileocolonic disease localisation, an upper gastrointestinal tract involvement, the use of steroids at the first Crohn’s disease occurrence and history of postoperative complications. These findings are similar to those in the countries with a high prevalence of Crohn’s disease.Data are available on reasonable request. The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request. ER -