RT Journal Article
SR Electronic
T1 Novel host genetic variations associated with spontaneous clearance of a single-source outbreak of HCV1b infections
JF BMJ Open Gastroenterology
FD BMJ Publishing Group Ltd
SP e000010
DO 10.1136/bmjgast-2014-000010
VO 1
IS 1
A1 Hong You
A1 Sandu Liu
A1 Yong Xie
A1 Rui Cong
A1 Yameng Sun
A1 Jingjing Ren
A1 Kangfei Wei
A1 Xin Jin
A1 Yujian Shi
A1 Haiying Zhang
A1 Jie Li
A1 Lai Wei
A1 Hui Zhuang
A1 Mingliang Cheng
A1 Jidong Jia
YR 2014
UL http://bmjopengastro.bmj.com//content/1/1/e000010.abstract
AB Background and aims A total of 105 patients were identified as accidentally infected with hepatitis C virus genotype 1b (HCV1b) through blood transfusion from a single blood donor. This group provides a unique patient population to study host factors involved in the spontaneous clearance of HCV and disease progression.Methods Clinical markers, HCV RNA and eight single nucleotide polymorphisms (SNPs) of interleukin-28B (IL-28B) were detected. Exome capture and sequencing were analysed for association with HCV clearance.Results Among the 85 patients with the positive HCV antibody, 27 cases (31.8%) were HCV RNA negative over a period of 9–12 years. Of the 58 patients with positive HCV RNA, 22.4% developed chronic hepatitis, and 5.2% developed cirrhosis. Age was found to be associated with HCV1b clearance. IL-28 rs10853728 CC showed the trend. By exon sequencing, 39 SNPs were found to be significantly different in spontaneous clearance patients (p<0.001). Two SNPs in the tenascin receptor (TNR), five in the transmembrane protease serine 11A (TMPRSS11A), and one in the serine peptidase inhibitor kunitz type 2 (SPINT2) showed the closest associations (p<10−5).Conclusions Host genetic analyses on the unique, single source HCV1b-infected patient population has suggested that age and mutations in TNR, TMPRSS11A and SPINT2 genes may be factors associated with HCV clearance.