RT Journal Article SR Electronic T1 Effect of COVID-19 on presentations of decompensated liver disease in Scotland JF BMJ Open Gastroenterology JO BMJ Open Gastro FD BMJ Publishing Group Ltd SP e000795 DO 10.1136/bmjgast-2021-000795 VO 9 IS 1 A1 Thomas Manship A1 Paul N Brennan A1 Iona Campbell A1 Stewart Campbell A1 Thomas Clouston A1 John F Dillon A1 Ewan Forrest A1 Andrew Fraser A1 Tee Lin Goh A1 Michael Johnston A1 Muhammad I Khan A1 Victoria Livie A1 Iain A Murray A1 Jayne Saunders A1 Debbie Troland A1 Ken J Simpson YR 2022 UL http://bmjopengastro.bmj.com//content/9/1/e000795.abstract AB Background and aims SARS-CoV-2 and consequent pandemic has presented unique challenges. Beyond the direct COVID-related mortality in those with liver disease, we sought to determine the effect of lockdown on people with liver disease in Scotland. The effect of lockdown on those with alcohol-related disease is of interest; and whether there were associated implications for a change in alcohol intake and consequent presentations with decompensated disease.Methods We performed a retrospective analysis of patients admitted to seven Scottish hospitals with a history of liver disease between 1 April and 30 April 2020 and compared across the same time in 2017, 2018 and 2019. We also repeated an intermediate assessment based on a single centre to examine for delayed effects between 1 April and 31 July 2020.Results We found that results and outcomes for patients admitted in 2020 were similar to those in previous years in terms of morbidity, mortality, and length of stay. In the Scotland-wide cohort: admission MELD (Model for End-stage Liver Disease) (16 (12–22) vs 15 (12–19); p=0.141), inpatient mortality ((10.9% vs 8.6%); p=0.499) and length of stay (8 days (4–15) vs 7 days (4–13); p=0.140). In the Edinburgh cohort: admission MELD (17 (12–23) vs 17 (13–21); p=0.805), inpatient mortality ((13.7% vs 10.1%; p=0.373) and length of stay (7 days (4–14) vs 7 days (3.5–14); p=0.525)).Conclusion This assessment of immediate and medium-term lockdown impacts on those with chronic liver disease suggested a minimal effect on the presentation of decompensated liver disease to secondary care.All data relevant to the study are included in the article or uploaded as supplementary information.