RT Journal Article
SR Electronic
T1 Enteropathies with villous atrophy but negative coeliac serology in adults: current issues
JF BMJ Open Gastroenterology
JO BMJ Open Gastro
FD BMJ Publishing Group Ltd
SP e000630
DO 10.1136/bmjgast-2021-000630
VO 8
IS 1
A1 Schiepatti, Annalisa
A1 Cincotta, Marta
A1 Biagi, Federico
A1 Sanders, David S
YR 2021
UL http://bmjopengastro.bmj.com//content/8/1/e000630.abstract
AB Objective The differential diagnosis and management of seronegative enteropathies is challenging due to the rarity of these conditions, the overlap of clinical and histopathological features and the current lack of an international consensus on their nomenclature.Design This is a narrative review providing pragmatic guide on the investigation and clinical management of seronegative enteropathies in adults based on the available literature and our clinical experience.Conclusions Seronegative coeliac disease is the most frequent cause among the heterogeneous group of seronegative enteropathies and its diagnosis is confirmed by the clinical and histological response to a gluten-free diet after the exclusion of other causes of villous atrophy. Correct identification and targeted management of seronegative enteropathies is mandatory because of the variation in terms of clinical outcomes and prognosis.No data are available. Not applicable.