@article {Yagie000662, author = {Sen Yagi and Shinya Furukawa and Kana Shiraishi and Yu Hashimoto and Kazuhiro Tange and Kenichirou Mori and Tomoyuki Ninomiya and Seiyuu Suzuki and Naozumi Shibata and Hidehiro Murakami and Katsuhisa Ohashi and Aki Hasebe and Hideomi Tomida and Yasunori Yamamoto and Eiji Takeshita and Yoshio Ikeda and Yoichi Hiasa}, title = {Effect of disease duration on the association between serum albumin and mucosal healing in patients with ulcerative colitis}, volume = {8}, number = {1}, elocation-id = {e000662}, year = {2021}, doi = {10.1136/bmjgast-2021-000662}, publisher = {BMJ Specialist Journals}, abstract = {Objective Serum albumin is used as a marker of acute inflammation. Several studies have addressed the association between serum albumin and clinical outcome in patients with ulcerative colitis (UC). While mucosal healing (MH) has been indicated as the therapeutic goal for UC, the association between serum albumin and MH remains unclear. We evaluated this issue in patients with UC overall and explored whether duration of UC affected this association.Design This cross-sectional study recruited consecutive patients with UC. Study subjects consisted of 273 Japanese patients with UC. Serum albumin was divided into tertiles based on its distribution in all study subjects. One endoscopy specialist was responsible for measuring partial MH and MH, which were defined as a Mayo endoscopic subscore of 0{\textendash}1 and 0, respectively. The association between serum albumin and clinical outcomes was assessed by multivariate logistic regression.Results Rates of clinical remission, partial MH and MH were 57.9\%, 63\% and 26\%, respectively. Only high serum albumin (\>4.4 mg/dL) was significantly positively associated with MH (OR 2.29 (95\% CI: 1.03 to 5.29), p for trend=0.043). In patients with short UC duration (\<7 years) only, high serum albumin was significantly positively associated with MH and clinical remission. In patients with long UC duration (>=7 years), in contrast, no association between serum albumin and clinical outcomes was found.Conclusion In Japanese patients with UC, serum albumin was significantly positively associated with MH. In patients with short UC duration, serum albumin might be a useful complementary marker for MH.Data are available upon reasonable request. The data sets used and/or analysed during the current study are available from the corresponding author on reasonable request.}, URL = {https://bmjopengastro.bmj.com/content/8/1/e000662}, eprint = {https://bmjopengastro.bmj.com/content/8/1/e000662.full.pdf}, journal = {BMJ Open Gastroenterology} }