RT Journal Article
SR Electronic
T1 Risk of colorectal cancer in a population-based study 20 years after diagnosis of ulcerative colitis: results from the IBSEN study
JF BMJ Open Gastroenterology
JO BMJ Open Gastro
FD BMJ Publishing Group Ltd
SP e000361
DO 10.1136/bmjgast-2019-000361
VO 7
IS 1
A1 Pasquale Klepp
A1 Stephan Brackmann
A1 Milada Cvancarova
A1 Marte Lie Hoivik
A1 Øistein Hovde
A1 Magne Henriksen
A1 Gert Huppertz-Hauss
A1 Tomm Bernklev
A1 Ole Hoie
A1 Iril Kempski-Monstad
A1 Inger Camilla Solberg
A1 Njaal Stray
A1 Jorgen Jahnsen
A1 Morten H Vatn
A1 Bjorn Moum
YR 2020
UL http://bmjopengastro.bmj.com//content/7/1/e000361.abstract
AB Objective The association between ulcerative colitis (UC) and colorectal cancer (CRC) is widely accepted, although attenuated risk has been reported in recent years. Colonoscopic surveillance is recommended with intervals based on established clinical risk factors. Nevertheless, a significant number of patients develop interval cancers, indicating the need of improved individualised assessment. In the present study, we evaluated clinical risk factors associated with CRC during a prescheduled follow-up 20 years after diagnosis, the IBSEN study.Design A population-based inception cohort of patients diagnosed with inflammatory bowel disease from 1 January 1990 until 31 December 1993, prospectively followed at 1, 5, 10 and 20 years after diagnosis. A total of 517 patients with UC were included; 264 (51 %) men; median age at inclusion 37.4 years (4–88).Results The overall incidence of CRC was 1.6% (8/517) at a 20-year follow-up. The total lifetime risk of CRC prior to or after UC diagnosis was 2.3%. (12/517). Patients older than 70 years at diagnosis had a 15-fold higher risk of CRC compared with those diagnosed when younger than 40 years, with HR 15.68 (95% CI: 1.31 to 187.92). Neither sex, first-degree relative with CRC, extent of colitis nor primary sclerosing cholangitis affected the risk of CRC.Conclusion The risk of CRC in UC was low and comparable with the risk of CRC in the background population of Norway.