Sirtuins (SIRTs) are nicotine adenine dinucleotide (+)-dependent histone deacetylases
regulating critical signaling pathways in prokaryotes and eukaryotes, and are involved in …

Nonalcoholic fatty liver disease (NAFLD), recently renamed metabolic-associated fatty liver
disease (MAFLD), is one of the most common causes of liver diseases worldwide. NAFLD is …

Background Nicotinamide adenine dinucleotide (NAD+), a critical coenzyme present in
every living cell, is involved in a myriad of metabolic processes associated with cellular …

Nicotinamide riboside (NR) has recently become one of the most studied nicotinamide
adenine dinucleotide (NAD+) precursors, due to its numerous potential health benefits …

Fatty liver diseases, which are commonly associated with high-fat/calorie diet, heavy alcohol
consumption and/or other metabolic disorder causes, lead to serious medical concerns …

Non-alcoholic fatty liver disease (NAFLD) is the first cause of chronic liver disease
worldwide; it ranges from simple steatosis to steatohepatitis (NASH) and, potentially …

Inflammation is an adaptive response in pursuit of homeostasis reestablishment triggered by
harmful conditions or stimuli, such as an infection or tissue damage. Liver diseases cause …

Background Hepatic steatosis is a common chronic liver disease that can progress into more
severe stages of NAFLD or promote the development of life-threatening secondary diseases …

Vitamin D (calciferol) is a fat-soluble vitamin that has a significant role in phospho-calcium
metabolism, maintaining normal calcium levels and bone health development. The most …

Nicotinamide adenine dinucleotide (NAD+) biosynthesis and its regulation have recently
been attracting markedly increasing interest. Aging is marked by a systemic decrease in …