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Rare case of EBV-induced colitis in an immunocompetent individual
  1. Catherine Choi1,
  2. Qi Yu2,
  3. Pratik Q Deb3,
  4. Weizheng Wang2
  1. 1Department of Medicine, Rutgers New Jersey Medical School, Newark, New Jersey, USA
  2. 2Gastroenterology and Hepatology Division, Department of Medicine, Rutgers New Jersey Medical School, Newark, New Jersey, USA
  3. 3Department of Pathology, Immunology & Laboratory Medicine, Rutgers New Jersey Medical School, Newark, New Jersey, USA
  1. Correspondence to Dr Weizheng Wang; wangww{at}


Epstein-Barr virus (EBV) is a member of the herpes virus family and affects people worldwide. EBV-infected colitis can occur in patients in immunocompromised states. However, EBV-induced colitis in immunocompetent patients is extremely rare. A 34-year-old man with a prior history of possible intussusception, and who underwent a right hemicolectomy, presented with abdominal pain and rectal bleeding. Laboratory investigations were unremarkable, and the patient underwent a colonoscopy, which showed EBV-infected colitis. Both infectious and inflammatory bowel disease (IBD) workups were negative. The patient’s symptoms were resolved with supportive therapy. A repeat colonoscopy showed normal colonic mucosa with an absence of EBV infection. Without evidence of IBD or infectious aetiologies, EBV-associated colitis is a rare finding in an immunocompetent patient.

  • infective colitis
  • inflammation
  • colonic diseases

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  • Contributors CC reviewed the literature and wrote the manuscript. QY edited the manuscript. WW designed the manuscript. PD provided the pathology slides and annotated the figures.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data availability statement Data sharing not applicable as no data sets generated and/or analysed for this study. No data are available. None.

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