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Abstract
Objective To describe an example of adult-onset autoimmune enteropathy (AIE) that coincided with drug-induced reaction.
Design A 54-year-old patient was presented with Stevens-Johnson syndrome after a course of quinolones. This was followed shortly thereafter by epigastric pain, diarrhoea and weight loss. She also developed an autoimmune neutropenia.
Results Several biopsies were performed from the upper and lower gastrointestinal tract (GIT). The duodenal biopsies showed intraepithelial lymphocytosis; therefore, coeliac disease was considered. However, confirmatory serology was negative and the patient did not respond to a gluten-free/gliadin-free diet. Both upper and lower GIT biopsies consistently showed an absence of goblet cells resembling the changes of an AIE.
Conclusion This is an unusual case of autoimmune-pattern enteropathy in an adult that was potentially drug-induced.
- autoimmune disease
- enteropathy
- drug toxicity
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Footnotes
Contributors RC, MC and AO all contributed equally to the planning, conduct and reporting of the work described in the article. RC is responsible for the overall content as guarantor.
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests None declared.
Patient consent for publication Obtained.
Provenance and peer review Not commissioned; externally peer reviewed.
Data availability statement There are no data in this work. No data are available.