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Weight regain after Roux-en-Y gastric bypass has a large negative impact on the Bariatric Quality of Life Index
  1. Pichamol Jirapinyo1,2,
  2. Barham K Abu Dayyeh3,
  3. Christopher C Thompson1,2
  1. 1 Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women’s Hospital, Boston, Massachusetts, USA
  2. 2 Harvard Medical School, Boston, Massachusetts, USA
  3. 3 Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA
  1. Correspondence to Dr Christopher C Thompson; cthompson{at}


Background Despite initial successful weight loss, some patients may experience weight regain following Roux-en-Y gastric bypass (RYGB).

Objective To assess the impact of weight regain on bariatric patients’ quality of life (QoL).

Methods This was a prospective cross-sectional study. Fifty-six consecutive RYGB patients were recruited and divided into weight-regain and weight-stable cohorts. QoL was assessed using the Bariatric Quality of Life (BQL) questionnaire. The BQL Index scores of the weight-regain and weight-stable groups were compared using Student’s t-test. Additionally, the BQL Index score of the weight-regain group was compared with that of historical prebariatric patients. Predictors of BQL were assessed using univariate and multivariate linear regression analyses.

Results Of 56 RYGB patients, 41 (73%) had weight regain. On average, patients had body mass index (BMI) of 37 ±7.5 kg/m2 and gained 34 ±26% of maximal weight initially lost. Weight-regain patients had lower BQL Index scores than weight-stable patients (44.8±6 vs 53±7, p<0.001). Patients with weight regain had similar BQL Index scores as the prebariatric patients despite lower BMI (BMI of 39.7±6.8 vs 47.2±7.6, p<0.05; BQL Index of 44.8±6 vs 41.6±10.4, p=0.144, respectively). Years from RYGB, BMI and amount of weight regain were associated with BQL Index on a univariate analysis (β=−0.55,−0.52, −0.7; p<0.0001). Only weight regain was a significant predictor of BQL on a multivariate analysis (β =−0.56; p=0.001).

Conclusion Weight regain had a negative impact on bariatric patients’ QoL. Patients who regained at least 15% of maximal weight lost appeared to have as low QoL as those who had not undergone bariatric surgery despite a lower BMI.

  • weight regain
  • bariatric surgery
  • RYGB
  • quality of life
  • HRQL
  • BQL

This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:

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  • Contributors PJ: data collection and analysis; drafting of the manuscript. BKAD: data collection and analysis. CT: study design, critical revision of the manuscript.

  • Funding The project was supported by the Clinical Translational Science Award from the National Center for Research Resources (UL1RR025758) and the Harvard Digestive Diseases Center at Harvard Medical School (DK034854).

  • Competing interests None declared.

  • Ethics approval Institutional review board.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data sharing statement Inquiries regarding access to the data should be addressed to the corresponding author and will be reviewed by the institutional review board.

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