The discovery of a large array of tumor antigens has demonstrated that host lymphocytes
can indeed recognize and destroy tumor cells as originally proposed in the cancer …

The natural killer T (NKT) cell ligand α-galactosylceramide (α-GalCer) exhibits profound
antitumor activities in vivo that resemble interleukin (IL)-12–mediated antitumor activities …

Regulated increase in the formation of microtubule arrays is thought to be important for
axonal growth. Collapsin response mediator protein-2 (CRMP-2) is a mammalian …

The role of T helper type 1 (Th1) and Th2 cells in tumor immunity was investigated using Th
cells induced from ovalbumin (OVA)-specific T cell receptor transgenic mice. Although Th1 …

In cultured hippocampal neurons, one axon and several dendrites differentiate from a
common immature process 1. Here we found that CRMP-2/TOAD-64/Ulip2/DRP-2 (refs. 2–4) …

Pacemaker treatment for bradyarrhythmia was first approved for national health insurance
coverage in Japan in 1974, and its use rapidly became widespread thereafter …

A polarity complex of PAR-3, PAR-6 and atypical protein kinase C (aPKC) functions in
various cell-polarization events, including neuron specification,,,. The small GTPase Cdc42 …

Migrating cells extend protrusions to establish new adhesion sites at their leading edges.
One of the driving forces for cell migration is the directional trafficking of cell-adhesion …

Drosophila neural precursor cells divide asymmetrically by segregating the Numb protein
into one of the two daughter cells. Numb is uniformly cortical in interphase but assumes a …

To investigate the precise role of antigen-specific Th1 and Th2 cells in tumor immunity, we
developed a novel adoptive tumor-immunotherapy model using OVA-specific Th1 and Th2 …