Clinical–Alimentary TractRandom Comparison of Guaiac and Immunochemical Fecal Occult Blood Tests for Colorectal Cancer in a Screening Population
Section snippets
Population
The population in this prospective study was a random selection of the general Dutch population between 50 and 75 years of age in Nijmegen, Amsterdam, and surrounding areas. Population data with respect to date of birth, gender, and postal area were provided by the civil service of the municipalities and updated every 8 weeks to keep the database up to date with respect to moving, age, and death. Institutionalized and symptomatic people were excluded. Symptomatic people were advised to contact
Population
Overall 20,623 individuals were invited; 10,301 received a G-FOBT and 10,322 an I-FOBT (Figure 1). The mean age of the invited individuals was 60.7 ± 7.1 years (mean ± SD) and was not different between the FOBT groups. More women than men were randomly selected with a difference of 3.4% (95% CI, 2.5–4.4; P < .01). After test allocation, gender differences were equal for both tests (Table 1).
Tests were returned by 10,993 individuals, 4836 (46.9%) in the G-FOBT group and 6157 (59.6%) in the
Discussion
In this population study, we randomly compared the performance of a G-FOBT with an I-FOBT in a previously screening naïve population.33 Another study comparing G-FOBT (Hemoccult-II) with I-FOBT was not randomized, included far fewer persons, and used a different I-FOBT. This I-FOBT(!nform) was not quantitative, making quality control less adequate.10 Despite these drawbacks, the results of this study were in line with ours. Other studies evaluating I-FOBTs included far less subjects and did not
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Supported by the Netherlands Organization for Health Research and Development (ZonMW: number 50-50115-98-060, project 63000004). This organization had no influence on any aspect relevant to this study.
This trial is registered under ISRCTN57917442 at Current Controlled Trials (www.controlled-trials.com).