Gastric lesions in familial adenomatosis coli: Their incidence and histologic analysis

doi:10.1016/S0046-8177(78)80085-9

Human Pathology

Volume 9, Issue 3, May 1978, Pages 269-283

https://doi.org/10.1016/S0046-8177(78)80085-9 Get rights and content

Abstract

In order to detect accompanying gastric lesions, we examined 22 patients with familial adenomatosis of the colon belonging to 14 families. Various gastric lesions were confirmed in 15 patients (68.2 per cent) belonging to 13 families. The lesions were found histologically to be adenoma in nine cases, fundic gland polyposis in six, carcinoma in three, and microcarcinoid in two. Fundic gland polyposis consisting of simple hyperplasia of the fundic glands seems to be the gastric lesion specific to familial adenomatosis of the colon and rectum. Familial adenomatosis coli not only affects the colon and rectum, but is also capable of inducing tumorigenicity in other organs. The stomach is one of the organs in which extracolonic lesions occur.

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^*: Study supported by Grants-in-Aid for Cancer Research in 1974 and 1975 from the Ministry of Education, Science and Culture, and in 1975 from the Ministry of Health and Welfare, Japan.

^†: Reported, in part, in the Proceedings of the 31st Annual Meeting, Japanese Cancer Association. Nagoya, 1972, in Gastroenterology (73:1086, 1977) and Acta Path. Jap. (27:823, 1979).

^‡: Associate Professor, Second Department of Pathology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.

^§: Professor, Second Department of Pathology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.

^‖: Lecturer, Second Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.

^¶: Lecturer, First Department of Surgery, Faculty of Medicine, Kyushu University, Fukuoka, Japan.

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Gastric lesions in familial adenomatosis coli: Their incidence and histologic analysis*,†

Abstract

Familial polyposis coli associated with extracolonic abnormalities

Gut

Multiple primary malignancies arising in the rectum, brain, and thyroid. Report of a case

U.S. Navy Med. Bull.

Gardner's syndrome and a new dental discovery

Oral Surg.

Multiple cutaneous and subcutaneous lesions occurring simultaneously with hereditary polyposis and osteomatosis

Amer. J. Hum. Genet.

Familial adenomatosis of the colon associated with brain tumor (Turcot's syndrome). Report of a case with review of the literature

Stom. Intest.

The nature of the mutation in familial multiple polyposis. Papillary carcinoma of the thyroid, brain tumors and familial multiple polyposis

Dis. Colon Rectum

Malignant tumors of the central nervous system associated with familial polyposis of the colon. Report of two cases

Dis. Colon Rectum.

The occult osteomatous changes in the mandible in patients with familial polyposis coli

Brit. J. Surg.

Diffuse familial polyposis of the colon

Surg. Gynec. Obstet.

Über Polyposis intestinalis adenomatosa und deren Beziehungen zur Krebsentwicklung

Arch. Klin. Med.

Involvement of the stomach in familial polyposis of the gastrointestinal tract. Report of a family

Gastroenterology

Familial polyposis of the entire gastrointestinal tract

Arch. Surg.

Polyp und Carcinom im Magen-Darmkanal

Beitr. Klin. Chir.

Polyposis of the stomach and small intestine in association with familial polyposis coli

Brit. J. Surg.

Follow-up study on upper gastrointestinal lesions in familial polyposis of the colon

Jap. J. Gastroenterol.

Lesions associated with the so-called familial polyposis of the colon

Stom. Intest.

Gastric lesion of familial polyposis of the large intestine

Cancer