Induction of neutrophil-attracting chemokines in transforming rat hepatic stellate cells
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Inflammatory pathways in alcoholic steatohepatitis
2019, Journal of HepatologyCitation Excerpt :TLR2 and TLR9 activation mediates the release of CXCL1 by hepatocytes and hepatic stellate cells (HSCs), promoting transient neutrophilic infiltration after alcohol binge.64 TLR4 activation may also take place in HSCs, repressing the TGFβ pseudoreceptor Bambi and thereby activating the fibrogenic TGFβ pathway,65 as well as leading to NF-κB activation, upregulation of chemokines and adhesion molecules, and recruitment of inflammatory cells.66,67 The inflammasome is a multiprotein oligomer composed of pro-CASP1, PYCARD, and NLRP, which mediates pro-CASP1 activation and subsequent processing of pro-IL-1β and pro-IL-18 by active CASP1.
The comparative efficacy of renin-angiotensin system blockers in schistosomal hepatic fibrosis
2018, Experimental ParasitologyCitation Excerpt :During chronic liver diseases, HSC undergo an activation process for a phenotype similar to myofibroblasts, characterized by increased expression of α-SMA smooth muscle actin (α-SMA) and enhanced proliferation, motility, contractility, and collagen synthesis, and components of the extracellular matrix (Knittel et al., 1999). Thus, HSC are closely involved in maintaining fibrosis and portal hypertension (Sprenger et al., 1997). The relationship of the hepatic fibrogenesis with components of the renin angiotensin system (RAS) has been extensively studied.
MicroRNA-29a mitigation of toll-like receptor 2 and 4 signaling and alleviation of obstructive jaundice-induced fibrosis in mice
2018, Biochemical and Biophysical Research CommunicationsMonitoring of Liver Fibrogenesis and Biochemical Diagnosis of Fibrosis
2017, Liver Pathophysiology: Therapies and Antioxidants