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Aperitif Effects on Gastric Emptying: A Crossover Study Using Continuous Real-Time 13C Breath Test (BreathID System)

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Abstract

The aim of this study was to determine whether there is a correlation between aperitif and gastric emptying. Ten healthy male volunteers participated in this randomized, two-way crossover study. Under two conditions (after drinking an aperitif versus not), the 13C breath test was performed for 4 h with a liquid meal (200 kcal/200 ml) containing 100 mg 13C acetate. We used 50 ml of umeshu as the aperitif. This is a traditional Japanese plum liqueur, and contains 7 ml alcohol (14%). In the aperitif group, T 1/2, T lag, and T peak were significantly delayed [T 1/2 (132: 113–174) versus (112: 92–134) (P = 0.0069); T lag (80: 63–94) versus (55: 47–85) (P = 0.0069); and T peak (81: 62–96) versus (54: 34–84) (P = 0.0069), (median: range, aperitif versus control, min)]. Gastric emptying was significantly delayed in the aperitif group as compared with the control group. This study revealed that even a small amount of alcohol such as an aperitif may contribute to delayed gastric emptying.

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References

  1. Weiner E (1989) Oxford English dictionary, 2nd edn. Oxford University Press, London

    Google Scholar 

  2. Franke A, Nakchbandi IA, Schneider A, Harder H, Singer MV (2005) The effect of ethanol and alcoholic beverages on gastric emptying of solid meals in humans. Alcohol Alcohol 40:187–193. doi:10.1093/alcalc/agh138

    PubMed  CAS  Google Scholar 

  3. Franke A, Teyssen S, Harder H, Singer MV (2004) Effect of ethanol and some alcoholic beverages on gastric emptying in humans. Scand J Gastroenterol 39:638–644. doi:10.1080/00365520410005009

    Article  PubMed  CAS  Google Scholar 

  4. Mushambi MC, Bailey SM, Trotter TN, Chadd GD, Rowbotham DJ (1993) Effect of alcohol on gastric emptying in volunteers. Br J Anaesth 71:674–676. doi:10.1093/bja/71.5.674

    Article  PubMed  CAS  Google Scholar 

  5. Yokoo Y, Fujii W, Hori H et al (2004) Isolation of stimulants of gastrointestinal motility in beer. Alcohol Clin Exp Res 28(8 Suppl Proceedings):129S–133S

    PubMed  CAS  Google Scholar 

  6. Fujii W, Hori H, Yokoo Y, Suwa Y, Nukaya H, Taniyama K (2002) Beer congener stimulates gastrointestinal motility via the muscarinic acetylcholine receptors. Alcohol Clin Exp Res 26:677–681. doi:10.1111/j.1530-0277.2002.tb02590.x

    Article  PubMed  CAS  Google Scholar 

  7. Nagao Y, Kodama H, Yonezawa T, Taguchi A, Fujino S, Nakahara K et al (1998) Correlation between the drinkability of beer and gastric emptying. Biosci Biotechnol Biochem 62:846–851. doi:10.1271/bbb.62.846

    Article  PubMed  CAS  Google Scholar 

  8. Israeli E, Ilan Y, Meir SB, Buenavida C, Goldin E (2003) A novel 13C-urea breath test device for the diagnosis of Helicobacter pylori infection: continuous online measurements allow for faster test results with high accuracy. J Clin Gastroenterol 37:139–141. doi:10.1097/00004836-200308000-00009

    Article  PubMed  CAS  Google Scholar 

  9. Yamanaka H, Inamori M, Fujisawa N, Akimoto K, Akiyama T, Fujita K et al (2007) Two cases of Pyloduodenal stenosis: the efficiency of gastric emptying evaluation using 13C continuous breath test (BreathID system). Digestion 20:238

    Google Scholar 

  10. Inamori M, Akiyama T, Akimoto K, Fujita K, Takahashi H, Yoneda M et al (2007) Early effects of peppermint oil on gastric emptying: a crossover study using continuous real time 13C breath test (BreathID system). J Gastroenterol 42:539–542. doi:10.1007/s00535-007-2067-3

    Article  PubMed  CAS  Google Scholar 

  11. Shimoyama Y, Kusano M, Kawamura O, Zai H, Kuribayashi S, Higuchi T et al (2007) High-viscosity liquid meal accelerates gastric emptying. Neurogastroenterol Motil 19:879–886. doi:10.1111/j.1365-2982.2007.00972.x

    Article  PubMed  CAS  Google Scholar 

  12. Mossi S, Meyer-Wyss B, Beglinger C, Schwizer W, Fried M, Ajami A et al (1994) Gastric emptying of liquid meals measured noninvasively in humans with [13C] acetate breath test. Dig Dis Sci 39:107S–109S. doi:10.1007/BF02300386

    Article  PubMed  CAS  Google Scholar 

  13. Sanaka M, Anjiki H, Yamamoto T, Kuyama Y (2007) Rabeprazole delays gastric emptying of a nutrient liquid. J Gastroenterol Hepatol 22:1806–1809. doi:10.1111/j.1440-1746.2006.04763.x

    Article  PubMed  CAS  Google Scholar 

  14. Sanaka M, Yamamoto T, Anjiki H, Nagasawa K, Kuyama Y (2007) Effects of agar and pectin on gastric emptying and post-prandial glycaemic profiles in healthy human volunteers. Clin Exp Pharmacol Physiol 34:1151–1155. doi:10.1111/j.1440-1681.2007.04624.x

    Article  PubMed  CAS  Google Scholar 

  15. Ghoos YF, Maes BD, Geypens BJ, Mys G, Hiele MI, Rutgeerts PJ et al (1993) Measurement of gastric emptying rate of solids by means of a carbon-labeled octanoic acid breath test. Gastroenterology 104:1640–1647

    PubMed  CAS  Google Scholar 

  16. Franke A, Harder H, Singer MV (2004) Reliability of the [13C]-acetate breath test in the measurement of gastric emptying of ethanol solutions: a methodological study. Scand J Gastroenterol 39:722–726. doi:10.1080/00365520410005964

    Article  PubMed  CAS  Google Scholar 

  17. Gee C (2006) Does alcohol stimulate appetite and energy intake? Br J Community Nurs 11:298–302

    PubMed  Google Scholar 

  18. Lenz HJ, Ferrari-Taylor J, Isenberg JI (1983) Wine and five percent ethanol are potent stimulants of gastric acid secretion in humans. Gastroenterology 85:1082–1087

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Gastroenterology Division, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004, Japan

    M. Inamori, H. Iida, H. Endo, K. Hosono, T. Akiyama, K. Yoneda, K. Fujita, T. Iwasaki, H. Takahashi, M. Yoneda, A. Goto, Y. Abe, N. Kobayashi, K. Kubota & A. Nakajima

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  1. M. Inamori
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  2. H. Iida
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  3. H. Endo
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  4. K. Hosono
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  5. T. Akiyama
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  6. K. Yoneda
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  7. K. Fujita
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  8. T. Iwasaki
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  9. H. Takahashi
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  10. M. Yoneda
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  11. A. Goto
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  12. Y. Abe
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  13. N. Kobayashi
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  14. K. Kubota
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  15. A. Nakajima
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Correspondence to M. Inamori.

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Inamori, M., Iida, H., Endo, H. et al. Aperitif Effects on Gastric Emptying: A Crossover Study Using Continuous Real-Time 13C Breath Test (BreathID System). Dig Dis Sci 54, 816–818 (2009). https://doi.org/10.1007/s10620-008-0427-3

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  • DOI: https://doi.org/10.1007/s10620-008-0427-3

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