Table 4

Cox proportional hazards model for mortality for patients with HCC

CharacteristicsUnivariable analysisMultivariable analysis
HR (95% CI)P valueHR (95% CI)P value
Age, years1.03 (1.01 to 1.05)0.041.05 (1.01 to 1.09)0.04
Male1.05 (0.65 to 1.71)0.840.82 (0.43 to 1.55)0.54
Ethnicity
 Caucasian1 (Referent)1 (Referent)
 Latino/Hispanic0.51 (0.30 to 0.86)0.010.83 (0.42 to 1.60)0.57
 Asian0.52 (0.28 to 0.96)0.040.48 (0.21 to 1.10)0.08
 African-American1.62 (0.65 to 4.05)0.311.11 (0.37 to 3.35)0.86
 Other/Unknown0.91 (0.33 to 2.54)0.861.15 (0.26 to 5.05)0.86
Decompensation1.03 (0.68 to 1.55)0.900.99 (0.54 to 1.84)0.98
CPT score1.02 (0.91 to 1.15)0.731.08 (0.93 to 1.25)0.33
Surveillance
 >q12 months or none*1 (Referent)1 (Referent)
 q6–12 months†1.20 (0.70 to 2.06)0.501.11 (0.49 to 2.49)0.81
 q6 months‡0.32 (0.19 to 0.52)< 0.00010.34 (0.16 to 0.72)0.005
Curative HCC treatment0.23 (0.14 to 0.40)<0.00010.32 (0.17 to 0.61)0.001
Within Milan criteria0.52 (0.34 to 0.79)0.0020.69 (0.40 to 1.18)0.17
  • *Less often than every 12 months or none.

  • †Less often than every 6 months but more often than every 12 months.

  • ‡At least every 6 months.

  • CPT, Child-Pugh-Turcotte; HCC, hepatocellular carcinoma.