Comparison of clinical variables and miRs in patients with BMI >30 and in patients with BMI <30
| Obese (N=20) | Lean (N=24) | p Value | |
|---|---|---|---|
| Age (years) | 61.05 (8.82) | 63.71 (10.23 | 0.3047 |
| BMI (kg/m2) | 34.08±3.48 | 26.46±2.22 | <0.0001 |
| WCC (103/μL) | 12.17±20.27 | 6.83±1.68 | 0.0527 |
| Platelet (103/μL) | 221.75±45.73 | 211.04±51.16 | 0.4477 |
| Glucose (mg/dL) | 176.65±120.32 | 101.18±27.47 | 0.0270 |
| ALT (U/L) | 24.10±10.07 | 26.77±16.55 | 0.9800 |
| AST (U/L) | 20.30±7.64 | 22.83±8.86 | 0.2522 |
| Triglycerides (mg/dL) | 134.26±62.94 | 96.88±38.74 | 0.0352 |
| LDL (mg/dL) | 74.50±27.61 | 86.14±28.23 | 0.1612 |
| Total cholesterol (mg/dL) | 149.53±36.89 | 151.77±27.69 | 0.5594 |
| HDL (mg/dL) | 41.95±17.04 | 44.54±12.85 | 0.2929 |
| Gender (male) | 18±90.0% | 21±87.5% | 0.7947 |
| CAD/NAFLD status: N (%) | |||
| CAD and NAFLD | 14 (70.0%) | 18 (75.0%) | 0.7108 |
| Only NAFLD | 6 (30.0%) | 6 (25.0%) | 0.7108 |
| miR-145 | 1.42±1.00 | 2.41±1.80 | 0.03 |
| miR-161 | 0.59±1.19 | 0.15±0.14 | 0.03 |
| miR-211 | 41.26±20.40 | 57.56±25.45 | 0.03 |
| miR-241 | 0.28±0.29 | 0.16±0.13 | 0.03 |
| miR-146a | 2.13±1.40 | 2.90±1.36 | 0.04 |
| miR-30c | 6.92±4.99 | 11.00±6.92 | 0.02 |
p<0.05 is considered significant. Values are presented as mean and SD.
ALT, alanine aminotransferase; AST, aspartate aminotransferase; BMI, body mass index; CAD, coronary artery disease; GGT, γ-glutamyl transferase; HDL, high-density lipoprotein; LDL, low-density lipoprotein; miR, microRNA; NAFLD, non-alcoholic fatty liver disease; WCC, white cell count.