Pooled side effects*
| Side effects | Pungpapong et al,13 n/N (%) | Gutierrez et al,16 n/N (%) | Lutchman et al,15 n/N (%) | Gordon et al,17 n/N (%) | Pooled total, n/N (%) |
|---|---|---|---|---|---|
| Fatigue | 16/123 (13) | 17/61 (28) | 15/53 (28) | – | 48/237 (21) |
| Skin problems (rash, pruritus or photosensitivity) | 7/123 (6) | 7/61 (11) | 22/53 (42) | 2/17 (12) | 38/254 (15) |
| Headache | 6/123 (5) | 11/61 (18) | 4/53 (8) | 2/17 (12) | 23/254 (9% |
| GI symptoms (nausea or diarrhoea) | 6/123 (5) | – | 2/53 (4) | 4/17 (24) | 12/193 (6) |
| Dyspnoea | 5/123 (4) | – | – | – | |
| Insomnia | 2/123 (2) | – | 10/53 (19) | – |
*Proportions reported in all patients for each study with available side effect data.
GI, gastrointestinal.