List of criteria for diagnosis of cachexia according to Evans et al and Fearon et al with translation to our study methods
| Fearon et al's criteria | Evans et al's criteria | Translation in our study |
|---|---|---|
| Weight loss >5% in past 6 months without starvation | Weight loss >5% in past 12 months and underlying chronic disease | NRS, PG-SGA |
| And/or | Or | |
| Weight loss >2% and BMI<20 | BMI<20 | NRS, PG-SGA |
| And/or | And 3 out of next 5 criteria | |
| Abnormal biochemistry | ||
| CRP>5 mg/L | Standard blood test | |
| Hb<12 g/dL | Standard blood test | |
| Albumin <3.2 g/d | Standard blood test | |
| Fatigue | EORTC tiredness: score ≥66.7 | |
| Anorexia | EORTC appetite loss: score ≥3 | |
| Decreased muscle strength | Hand grip strength (dynamometer) | |
| Weight loss >2% and sarcopenia | Lean tissue depletion | BIA |
| Male SMI<7.26 kg/m2 | ||
| Female SMI<5.45 kg/m2 |
BIA, bioelectric impedance analyses; BMI, body mass index (kg/m2); CRP, C reactive protein; Hb, hemoglobin; NRS, Nutritional Risk Screening; PG-SGA, Patient-Generated Subjective Global Assessment; SMI, Skeletal Muscle mass Index.