Table 1

Baseline and follow-up characteristics of the four patients with collagenous sprue

Case	Gender	Follow-up (months)	Age (years)	Treatment	Clinical evaluation	Maximum thickness of BM (µm)	Villous atrophy	IEL (per 100 enterocytes)	Epithelial detachment	LP vessels entrapped in basement membrane
1	F	Baseline	77			14	Subtotal	12	>10% of surface	Present
		11		Budesonide	No improvement	21	Total	10	<10% of surface	Present
		18		6-MP	Small improvement	18	Total	12	>10% of surface	Present
		40		Budesonide and 6-TG	Improvement	2	Mild	6	<10% of surface	Absent
2	M	Baseline	79			34	Total	10	100%	Present
		9		Budesonide and 6-TG	Improvement	32	Total	24	25–50%	Present
		30		Budesonide and 6-TG	Improvement	21*	Subtotal	14	>50%	Present
3	F	Baseline	88			21	Total	12	>10% of surface	Present
3	F	10		Budesonide and 6-TG	Improvement	2	None	4	Absent	Absent
4	F	Baseline	76			19	Total	32	<10% of surface	Present
4	F	3		6-TG	Improvement	23	Total	14†	>10% of surface	Present

*Very focal. †Also some intraepithelial eosinophils.
6-MP, 6-mercaptopurine; 6-TG, 6-thioguanine; BM, basement membrane; F, female; IEL, intraepithelial lymphocytes; LP, lamina propria; M, male.