Parameters associated with the diagnosis of cachexia are demonstrated for cachectic patient groups according to the definition of Fearon et al (A) and for Evans et al (B)
| (A) Cachexia according to Fearon et al | (B) Cachexia according to Evans et al | |||||
|---|---|---|---|---|---|---|
| Parameter (Fearon et al, Evans et al) | Non-cachectic | Cachectic | Adjusted p value | Non-cachectic | Cachectic | Adjusted p value |
| Body weight | 74.32 (1.04) | 68.30 (1.04) | <0.0001 | 72.03 (1.04) | 68.28 (1.12) | <0.0001 |
| WLOSS (%/m) | 0.22 (0.13) | −1.42 (0.11) | <0.0001 | −0.36 (0.10) | −1.94 (0.20) | <0.0001 |
| BMI | 25.52 (0.30) | 23.46 (0.30) | <0.0001 | 24.75 (0.30) | 23.44 (0.33) | <0.0001 |
| Power (handgrip) | 32.75 (0.83) | 30.45 (0.82) | <0.0001 | 32.22 (0.79) | 29.09 (0.89) | <0.0001 |
| SMI | 8.88 (0.13) | 8.23 (0.13) | <0.0001 | 8.61 (0.13) | 8.30 (0.15) | 0.0145 |
| Albumin | 3.61 (0.05) | 3.47 (0.04) | 0.0657 | 3.67 (0.04) | 3.08 (0.06) | <0.0001 |
| CRP (log) | 0.34 (0.03) | 0.44 (0.02) | 0.0260 | 0.30 (0.02) | 0.69 (0.03) | <0.0001 |
| Parameters (extra) | ||||||
| Energy need | 1489.71 (13.50) | 1423.56 (13.28) | <0.0001 | 1470.16 (12.65) | 1406.26 (14.84) | <0.0001 |
| Protein need | 89.77 (1.28) | 82.44 (1.26) | <0.0001 | 87.01 (1.25) | 82.39 (1.41) | <0.0001 |
| RZ | 525.90 (7.10) | 571.52 (6.93) | <0.0001 | 544.01 (6.74) | 571.61 (8.38) | <0.0001 |
| XC | 48.18 (1.05) | 50.03 (1.01) | 0.3924 | 50.05 (0.91) | 46.61 (1.26) | 0.0145 |
| PA | 5.24 (0.09) | 5.00 (0.08) | 0.0657 | 5.25 (0.07) | 4.67 (0.11) | <0.0001 |
| FFM | 55.53 (0.80) | 51.77 (0.80) | <0.0001 | 53.93 (0.79) | 52.18 (0.86) | 0.0007 |
| TBW | 39.75 (0.62) | 36.55 (0.62) | <0.0001 | 38.40 (0.62) | 36.83 (0.68) | <0.0001 |
| Quality of life | 61.45 (1.65) | 53.75 (1.53) | 0.0012 | 61.04 (1.27) | 44.04 (2.10) | <0.0001 |
Parameters as defined by Fearon et al and Evans et al: Body weight (kg), WLOSS (%/body mass), BMI (kg/m2), Power (handgrip), SMI (kg/m2), albumin (g/dl), CRP (log mg/L). Parameters additionally collected by the measurements: energy need (calories), protein need, RZ, XC, PA, FFM (kg/m2), TBW (%) and Quality of life (EORTC outcome score).
BMI, body mass index; CRP, C reactive protein; EORTC, European organisation for research and treatment of cancer; FFM, fat-free mass; PA, phase angle; RZ, resistance; SMI, skeletal muscle mass index; TBW, total body water; WLOSS, weight loss; XC, reactance.