Histopathological changes of the mucosa induced by hyperbaric oxygen therapy in patients with refractory ulcerative colitis
| Pathological feature | Median* (range) Pre-therapy | Median (range) Post-therapy | p Value† |
|---|---|---|---|
| Architectural changes | 0.3 (0.2–0.3) | 0.3 (0.2–0.3) | >0.05 |
| Chronic inflammation | 1.3 (1.2–1.3) | 1.1 (1–1.1) | <0.001 |
| Eosinophils in the lamina propria | 2.15 (2–2.5) | 2.05 (2–2.2) | <0.001 |
| Neutrophils in the lamina propria | 2.1 (2.0–2.1) | 2.0 (2.0–2.0) | <0.001 |
| Neutrophils in the epithelium | 3.3 (3.1–3.3) | 3.1 (3.1–3.2) | <0.001 |
| Crypt destruction | 4.3 (4.1–4.3) | 4.1 (4–4.1) | <0.001 |
| Surface erosions/ulcerations | 5.3 (5.2–5.3) | 5.1 (5.0–5.1) | <0.001 |
*The median was used to express the central tendency instead of the mean rank, to facilitate interpretation by the reader.
†p Value is estimated from Wilcoxon signed rank test.