Table 2

Predominant groups of bacteria

Per cent ratio of the abundance (Mean±SD)
FD
Bacterial groupHCBeforeAfter
Phyla (Top 3 in the FD)
Firmicutes31.6±10.436.0±5.730.1±9.4
Bacteroidetes13.5±5.424.2±8.9*19.4±7.5
Proteobacteria29.5±10.44.9±10.8*20.7±9.7
Acidobacteria3.8±4.20.2±0.8*9.7±12.7†
Number of subjects
Bacteroidetes > Proteobacteria/Bacteroidetes< Proteobacteria2/1919/5*12/12†
+ve/−ve samples of Acidobacteria16/51/23*19/5†
Genera (Top 10 in the FD)
Prevotella10.5±5.714.2±8.314.3±8.3
Streptococcus16.6±9.014.0±7.511.3±6.6
Bacteroides1.2±1.07.0±8.6*2.2±4.0†
Veillonella5.1±2.85.6±3.35.9±4.2
Neisseria7.2±6.14.1±5.65.0±5.5
Fusobacterium4.6±2.83.3±1.93.1±2.0
Leptotrichia0.3±0.30.6±0.80.6±0.8
Porphyromonas0.4±0.40.5±0.50.7±0.9
Edaphobacter3.8±4.20.2±0.8*9.7±12.7†
Species (Top 15 in the FD)
Haemophilus parainfluenzae6.0±3.44.3±4.83.9±3.0
Prevotella melaninogenica4.0±2.63.8±2.84.1±3.2
P. jejuni1.3±1.63.4±3.5*3.4±2.9
Bacteroides dorei0.2±0.13.0±6.0*0.3±0.5†
B. uniformis0.6±0.52.5±3.1*1.2±2.3
Neisseria subflava3.4±4.82.3±4.22.4±3.8
Veillonella atypica1.5±1.72.1±1.82.2±1.9
V. dispar1.9±1.72.1±1.62.5±2.4
P. pallens1.1±1.22.0±2.22.0±1.6
Fusobacterium periodonticum3.0±2.71.8±1.71.8±1.7
Granulicatella adiacens1.6±0.71.8±1.21.8±1.5
Streptococcus salivarius1.5±2.31.7±1.51.4±1.8
Escherichia/Shigella0.3±0.31.6±2.1*0.8±0.2†
Megamonas funiformis0.3±0.31.4±1.9*0.6±1.2
Bifidobacterium longum0.3±0.21.3±1.6*0.7±1.6
Edaphobacter aggregans3.8±4.20.2±0.8*9.7±12.7†

  • *p<0.05 between HC and FD before treatment.

  • †p<0.05 between before and after LG21 treatment.

  • FD, functional dyspepsia; HC, healthy control.