Table 3

Multivariate analysis: effect on clinical response of acid suppressants taken concurrently with CDAD-targeted antibiotics (mITT inpatients, n=701)

			95% CI
Variable	Comparison	Adjusted OR	Lower	Upper	p Value
PPI
Age category	10-year increase in age	0.934	0.805	1.083	0.3657
Serum albumin	<2.5 vs ≥2.5 mg/dL	0.493	0.317	0.767	0.0017
Serum creatinine	≥1.5 vs <1.5 mg/dL	0.543	0.336	0.876	0.0123
WCC	≥15×10⁹ vs <15×10⁹/L	0.614	0.380	0.994	0.0471
Treatment	Fidaxomicin vs vancomycin	1.373	0.892	2.112	0.1494
PPI use	Yes vs no	0.978	0.635	1.505	0.9184
H2RA
Age category	10-year increase in age	0.930	0.802	1.079	0.3408
Serum albumin	<2.5 vs ≥2.5 mg/dL	0.495	0.318	0.771	0.0019
Serum creatinine	≥1.5 vs <1.5 mg/dL	0.541	0.335	0.873	0.0119
WCC	≥15×10⁹ vs <15×10⁹/L	0.609	0.376	0.986	0.0439
Treatment	Fidaxomicin vs vancomycin	1.362	0.887	2.092	0.1577
H2RA use	Yes vs no	0.830	0.391	1.761	0.6268
PPI and/or H2RA
Age category	10-year increase in age	0.935	0.806	1.084	0.3734
Serum albumin	<2.5 vs ≥2.5 mg/dL	0.497	0.320	0.774	0.0020
Serum creatinine	≥1.5 vs <1.5 mg/dL	0.547	0.339	0.883	0.0135
WCC	≥15×10⁹ vs <15×10⁹/L	0.605	0.373	0.980	0.0411
Treatment	Fidaxomicin vs vancomycin	1.386	0.902	2.131	0.1365
PPI/H2RA use	Yes vs no	0.851	0.545	1.330	0.4786

Age category includes age in decade (≤40, 41–50, 51–60, 61–70, 71–80, and >80 years); hypoalbuminemia is serum albumin <2.5 g/dL; high serum creatinine level is ≥1.5 mg/dL; and leukocytosis is WCC ≥15×10⁹/L.
CDAD, Clostridium difficile-associated diarrhoea; H2RA, histamine-2 receptor antagonist; mITT, modified intent to treat; PPI, proton pump inhibitor; WCC, white cell count.