Risk of selected site-specific gastrointestinal cancers in patients with breast cancer (1990–2017), by calendar periods
| 1990–2006 | 2007–2017 | |||||
| O/E | IR per 100 000 PY (95% CI) | SIR (95% CI) | O/E | IR per 100 000 PY (95% CI) | SIR (95% CI) | |
| Gastrointestinal cancers overall | 864/814 | 270 (252 to 288) | 1.06 (0.99 to 1.14) | 512/451 | 323 (295 to 350) | 1.13 (1.04 to 1.24) |
| Upper gastrointestinal cancers | 135/95 | 42 (35 to 49) | 1.42 (1.19 to 1.68) | 55/53 | 35 (25 to 44) | 1.05 (0.79 to 1.36) |
| Oesophagus | 39/32 | 12 (8 to 16) | 1.21 (0.86 to 1.66) | 16/19 | 10 (5 to 15) | 0.85 (0.49 to 1.39) |
| Stomach | 78/52 | 24 (19 to 30) | 1.50 (1.19 to 1.87) | 34/25 | 21 (14 to 29) | 1.36 (0.94 to 1.90) |
| Small intestine | 18/11 | 6 (3 to 8) | 1.65 (0.98 to 2.60) | 5/9 | 3 (0 to 6) | 0.57 (0.19 to 1.34) |
| Lower gastrointestinal cancers | 558/543 | 175 (160 to 189) | 1.03 (0.94 to 1.12) | 371/306 | 234 (210 to 257) | 1.21 (1.09 to 1.34) |
| Colon incl. rectosigmoid colon | 378/379 | 118 (106 to 130) | 1.00 (0.90 to 1.10) | 278/215 | 175 (155 to 196) | 1.30 (1.15 to 1.46) |
| Rectum | 162/148 | 51 (43 to 59) | 1.10 (0.94 to 1.28) | 87/80 | 55 (43 to 66) | 1.09 (0.87 to 1.34) |
| Anal canal | 18/17 | 6 (3 to 8) | 1.06 (0.63 to 1.68) | 6/11 | 4 (1 to 7) | 0.53 (0.19 to 1.15) |
| Other gastrointestinal cancers | 171/175 | 54 (45 to 62) | 0.97 (0.83 to 1.13) | 86/93 | 54 (43 to 66) | 0.93 (0.74 to 1.15) |
| Liver | 22/27 | 7 (4 to 10) | 0.82 (0.51 to 1.24) | 10/16 | 6 (2 to 10) | 0.64 (0.31 to 1.19) |
| Gallbladder and biliary tract | 23/30 | 7 (4 to 10) | 0.77 (0.49 to 1.16) | 13/15 | 8 (4 to 13) | 0.87 (0.46 to 1.49) |
| Pancreas | 126/119 | 39 (33 to 46) | 1.06 (0.88 to 1.26) | 63/62 | 40 (30 to 49) | 1.01 (0.78 to 1.29) |
The analysis was restricted to 1–10 years of follow-up.
E, expected; IR, incidence rate; O, observed; PY, person years; SIR, standardised incidence ratio.