Overview of the characteristics of the at presently reported various types of EATL
| Characteristics | EATL type 1 | EATL type 2 | variant type EATL | AIE-associated T-cell lymphoma |
|---|---|---|---|---|
| Association with enteropathy | + | − | + | + |
| HLA-DQ2/-DQ8 | + | − | + | + |
| Putative precursor cell | CD3s−IEL | Clonal aberrant T-cell | Clonal γδ-T-cells | Clonal CD8 αβ-T-cells |
| Morphology | Polymorphic | Monomorphic | Polymorphic | Monomorphic |
| Phenotype | ||||
| CD3 | + | + | − | + |
| CD4 | Mostly− | − | − | − |
| CD5 | Mostly− | Mostly+(70%) | − | + |
| CD8 | Mostly−(20%+) | + | − | + |
| CD7 | + | + | + | − |
| CD15 | − | − | + | nd |
| CD20 | − | − | − | − |
| CD30 | Mostly+(80%) | − | + | +/− |
| CD56 | − | + | − | − |
| Granzyme | + | + | + | + |
| TIA1 | + | + | + | + |
| Chromosomal aberrantions | ||||
| Gains | 1q, 5q, 7q, 9q, | MYC, 7q, 8q, 9q | 7q | 7q |
| Loss | 8p, 13q,16q | 8p, 10q | ||
HLA, human leucocyte antigen.