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Colorectal disease
National complicated acute diverticulitis (CADS) study: a protocol for a prospective observational scoping study for acute diverticulitis
  1. Shafaque Shaikh1
  2. on behalf of the CADS Study Group
    1. 1Section of Molecular Gastroenterology, Leeds Institute of Biomedical and Clinical Sciences, University of Leeds, Leeds, UK
    2. 2The CADS Study Group, Leeds, UK
    1. Correspondence to Shafaque Shaikh; s.shaikh{at}leeds.ac.uk

    Abstract

    Background Diverticular disease is a widely prevalent disease in western society, and acute diverticulitis is a common acute surgical presentation. However, there is a lack of level 1 evidence addressing the multifaceted presentations associated with acute diverticulitis. There is also a lack of robust epidemiological data that could be used to meaningfully inform randomised controlled trials. The National CADS project aims to generate baseline data for a cohort of patients managed for clinically suspected acute diverticulitis and evaluate the impact of variability in the management approach on patient outcomes in the short (3 months) and long (2 years) term.

    Method A Unit policy questionnaire will be completed by the principal investigator from all participating centres prior to study initiation. All patients aged above 18 years admitted with clinical suspicion of acute diverticulitis will be included from UK hospitals providing acute surgical care. Demographic, clinical, inpatient stay and outpatient follow-up data will be collected for index admissions between July and September 2014, 3 months follow-up and finally a 2-year follow-up.

    Results The study attracted participation from 108 centres nationally and has so far generated data on 2500 patients admitted between 1 July 2014 and 30 September 2014. Short-term follow-up data have been obtained for this cohort.

    Conclusions The National CADS study is currently ongoing with the long-term outcomes data anticipated to be submitted in autumn of 2016.

    • COLORECTAL SURGERY
      • ,
    • DIVERTICULAR DISEASE
      • ,
    • SURGICAL COMPLICATIONS
      • ,
    • SURGICAL RESECTION

    This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/

    https://doi.org/10.1136/bmjgast-2016-000117

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      Footnotes

      • Twitter Follow Shafaque Shaikh at @cadsaudit

      • Collaborators Chief Investigators: SS, Chris Macklin, David Jayne. Steering committee: The National Surgical Research Collaborative: East of England Surgical Research Group (EESuRG)–Chris Challand; East Midlands Surgical Academic Network (EMSAN)–Ben Rees; London Surgical Research Group (LSRG)–Nick Symons; Mersey Research Group for General Surgery (MeRGS)–Andrea Sheel; North West Research Collaborative (NWRC)–Jennifer Smith; Severn and Peninsula Audit and Research Collaborative for Surgeons (SPARCS)–Natalie Blencowe; Scottish Surgical Research Collaborative (SSRG)–James Park; Student Audit and Research Training (STARsurg)–Stephen Chapman; South Yorkshire Surgical Research Group (SYSuRG)–Jonny Wild; Welsh Barbers Research Group (WBRG)–Julie Cornish; West Midlands Research Collaborative (WMRC)–Marianne Johnstone Warwickshire Surgical Research Group (WSRG)–Shameen Janau; Yorkshire Surgical Research Collaborative (YSRC)–SS, Greg Taylor, Stephen Chapman; Aberdeen Royal Infirmary: Zygmunt Krukowski, Emad Aly, Craig Parnaby; Addenbrooke's Hospital: Jonathan Morton, Nikolaos Chatzizacharias; Altnagelvin Area Hospital, Northern Ireland: Roger Lawther, Brendan L Skelly; Arrowe Park Hospital: Jim Anderson, Ramya Kalaiseran; Ashford and St Peter's Hospitals NHS Trust: Pasha Nisar, Jonathan van Dellen; Balfour Hospital, Orkney: Michael Dorhn; Bangor Hospital (Ysbyty Gwynedd): Anil Lala, Catherine Zabkiewicz; Barnet and Chase Farm Hospital: Pawan Mathur, Kanishk Shah; Barnstaple Hospital: Ceri Beaton, David Griffith; Blackpool Victoria Hospital: Jonathan Barker, Nick Heywood; Borders General Hospital: Ahmed Khalil, Roland Aldridge; Bradford Royal Infirmary: Sonia Lockwood, Martin Trotter; Bristol Royal Infirmary: Michael Thomas, Angus McNair; Cheltenham General Hospital: Damian Glancy, Simon Davey; Chesterfield Hospital: Harjeet Narula, Monica Bogdan, Rohan Ardley; Colchester Hospital University NHS Trust: Mathew Tutton, Yahya Al-Abed; Croydon University Hospital: Muti Abulafi, Gregory Thomas; Cumberland Infirmary Hospital: Ernest Jehangir, Abdul Ahad; Darent Valley Hospital, Kent: Rakesh Bhardwaj, Piero Nastro, Sarah Wheatstone; Derriford Hospital, Plymouth: Kenneth Hosie, Alex Reece-Smith; Diana Princess of Wales Hospital, Grimsby: Kishore Saaspu, Eyad Issa; Doncaster Royal Infirmary: Dan Beral, Jonny Wild; Dorset County Hospital Foundation Trust: Ben Stubbs, Gavin Smith; Dr Gray's Hospital, Elgin: Alan Grant, Angharad Jones; Forth Valley Hospital: Euan MacDonald, Mustafa Farhad; Furness General Hospital, Morcambe: Panna Patel, Sundara Rajan Shreekumar; George Elliot Hospital: Kalimuthu Marimuthu, David Naumann; Gilbert Bain Hospital, Shetland: Beatrix Weber; Glasgow Royal Infirmary: Paul Horgan, James Park; Gloucester Royal Infirmary: Mike Scott, Ken Keogh; Great Western Hospital, Swindon: Chris Thorn, Emma Upchurch; Heartlands Hospital, Birmingham: Sharad Karandikar, Ahmed Karim; Hillingdon Hospital, London: Alistair Myers, Aimee diMarco; Homerton University Hospital: Sanjaya Wijeyekoon, Pedro Cunha, Mustafa Al-Sheikh; Huddersfield Royal Infirmary: David Ilsley, George Markides; Hull Royal Infirmary: Iain Hunter, Jonathan Cowley; Ipswich Hospital: Michael Crabtree, Muraly Parthasarsthy; James Cook University Hospital: Madan Jha, WS Ngu; James Paget Hospital: Vamsi Velchuru, Andrew Moss; Kettering General Hospital: Saleem El-Rabaa, Gianpiero Gravante; King's College Hospital: Spyros Panagiotopoulos, Emmanouil Giorgakis; Leighton Hospital: Jonathan Hardman, Laura Balance; Luton and Dunstable Hospital: Firas Younis, Piriyah Sinclair; Medway Maritime Hospital, Kent: Shirley Chan, Ben O'Sullivan; Mid Yorkshire Hospitals NHS Trust: Adeshina Fawole, Christopher Macklin, Janahan Sarveswaran; Morriston Hospital: Martyn Evans, Nihit Rawat; Musgrove Park, Taunton: Paul Mackey, David Messenger; Ninewells Hospital, Dundee: Christopher Payne, Michael Wilson; Norfolk and Norwich University Hospital: James Hernon, Farhan Rashid; North Tyneside General Hospital: Seamus Kelly, Yousif Aawsaj; Northern General Hospital, Sheffield: Ian Adam, Tak Khong; Northwick Park Hospital: Lampros Liasis, Salman Bokhari, Laura Muirhead; Oxford University Hospitals NHS Foundation Trust: Chris Cunningham, Muhammad Atif; Perth Royal Infirmary: Alan Boyd, Andreas Luhmann; Peterborough City Hospital: Robert Dennis, Chris Challand; Princess Royal University Hospital: Rosaria Scarpinata, Ezzat Chohda; Queen Alexandra Hospital, Portsmouth: Ben Knight, Melanie Holman; Queen Elizabeth Hospital, Birmingham: Thomas Pinkney, Oroog Ali; Queen Elizabeth Hospital, Woolwich: Niall Ashton, Rajan Jandoo; Queen's Medical Centre, Nottingham: Austin Acheson, Yao Pey Yong; Raigmore Hospital, Inverness: Angus Watson, Umberto Pisano; Rotherham General Hospital: Richard Slater, Irene Athanasiou; Royal Albert Edward Infirmary, WWL NHS Trust: Iqbal Nasir, Nitya Krishnamohan; Royal Bolton Hospital: Dave Smith, Jennifer Smith; Royal Cornwall Hospital: Denzil May, Lisa Massey; Royal Derby Hospital: Jon Lund, Chris Neophytou; Royal Devon and Exeter Hospital: Ian Daniels, Theodora Stasinou; Royal Free Hospital: Massimo Varcada, Hany Nada; Royal Gwent Hospital, Newport: Gethin Williams, Harsha Jayamanne; Royal Hampshire Hospital: Tim Moore, Jack Broadhurst; Royal Lancaster Hospital: Thomas Raymond, Lynn Douglas; Royal Liverpool University Hospital: Richard M Heath, Philippa Wadsworth; Royal Preston Hospital: Nigel Scott, Reza Zadeh; Royal United Hospital, Bath: Mike Williamson, Sarah Richards, Alex Humphreys, Matthew Doe; Royal Victoria Infirmary, Newcastle upon Tyne: Stefan Plusa, Lucy Bookless; Royal Worchestershire Hospital: Miguel Zilvetti, Emma Hamilton; Salisbury District Hospital: Graham Branagan, Rupesh Sutaria; Scarborough Hospital: Mark Peter, Rizwan Aziz; Scunthorpe General Hospital: Ashraf Koronfel, Sharath Paravasthu; Sherwood Forest Hospitals NHS Trust: Nicholas Watson, Tanvir Sian; Southend University Hospital: Praveen Bandipalyam, Rebecca Himpson; Southmead Hospital, North Bristol NHS Trust: Anne Pullyblank, Chakri Munipalle; Southport and Omskirk Hospital: Dmitri Artioukh, Andrea Sheel; St James’ University Hospital, Leeds: David Jayne, Andrew Kirby, SS, Stephen Chapman, Rajveer Theti; St Mary's Hospital, Isle of Wight: Emily Cook, Robert Walker; Sunderland Royal Hospital: Stephen Holtham, Peter Coyne; The County Hospital, Hereford: Clare Cheek, George Galanopoulos; The Shrewsbury and Telford Hospital NHS Trust: Jon Lacy-Colson, Vijay Reddy University Hospital Coventry and Warwickshire: Christopher Harmston, Anne Gaunt; University Hospital Lewisham: Clare Byrne, Shruti Mittal; University Hospital of North Staffordshire: Christine Hall, Philip Varghese; University Hospital of North Tees and Hartlepool: Ous Alozairi, Matthew Toward; University Hospital of South Manchester: Abhiram Sharma, James Nicholson; University Hospital of Wales: Jared Torkington, Julie Cornish; West Middlesex University Hospital: Jason Smith, Matyas Fehervari; Western General Hospital, Edinburgh: Hugh Paterson, Nicholas Ventham; Western Infirmary, Glasgow: Paul Rogers, Brendan Skelly; Weston General Hospital: Krishna Kandaswamy, Rebecca Llewellyn Bennett, Melanie Orchard; Whipps Cross Hospital, Zaker Ullah, Jasmine Ho; Whiston Hospital: Sanjay Kanwar, Shantanu Singh; Whittington Hospital: Chetan Bhan, Sacheen Kumar; William Harvey Hospital, Kent: Pradeep Basnyat, Ashish Shrestha; Worthing Hospital: Pauline Whitehouse, Sameh Farag; Yeovil District Hospital: Nader Francis, Alison Luther; York Hospital: David Alexander, Greg Taylor, Kostas Polyzois.

      • Contributors SS is responsible for concept, study design, conduct, manuscript writing, submission. DGJ is responsible for manuscript review, supervision. CM is responsible for manuscript review, web support. CADS study group is responsible for manuscript review, recruitment and data collection.

      • Disclaimer The CADS core committee reserves the right to review and amend this protocol within reason during the course of the audit to enable delivery of the project to the highest standards.

      • Competing interests None declared.

      • Ethics approval MRC-Health Research Authority tool: http://www.hra-decisiontools.org.uk/research/.

      • Provenance and peer review Not commissioned; externally peer reviewed.